乳腺癌是女性常见的恶性肿瘤，属于中医“乳岩”“乳毒”“乳石痈”等范畴。黄芪Astragali Radix具有补气升阳、利水消肿、托毒排脓等功效，契合乳腺癌病理病机。现代研究表明，黄芪抗乳腺癌的活性成分主要是黄芪甲苷、黄芪多糖、毛蕊异黄酮、芒柄花素、槲皮素等，作用机制包括抑制乳腺癌细胞增殖、诱导细胞凋亡、抑制细胞侵袭和迁移、抑制乳腺癌血管生成、抗雌激素作用、调节巨噬细胞极化、增强机体免疫力、增强化疗药物敏感性及协同增效等途径阻碍乳腺癌的发生发展，具有多成分、多靶点、多通路的特点。通过对黄芪及活性成分抗乳腺癌作用及其分子机制进行综述，为黄芪抗乳腺癌的深入研究和新药开发提供参考依据。

Breast cancer is a common malignant tumor in women, which belongs to the categories of “ruyan” “rudu” and “rushiyong” in traditional Chinese medicine. Huangqi (Astragali Radix) has the effects of invigorating vital energy and raising yang, promoting diuresis to relieve edema, draining pus and expelling toxin, etc., which fits the pathological mechanism of breast cancer. Modern research shows that the active ingredients of Astragali Radix against breast cancer are mainly astragaloside IV, astragalus polysaccharide, calycosin, formononetin, quercetin, etc. The mechanism of action includes inhibiting breast cancer cells proliferation, inducing cell apoptosis, inhibiting cell invasion and migration, inhibiting breast cancer angiogenesis, anti-estrogenic effect, regulating macrophages polarization, enhancing body immunity, enhancing chemotherapy drugs sensitivity, and synergistic interaction to hinder the occurrence and development of breast cancer. Astragali Radix anti-breast cancer reflects the characteristics of multi-component, multi-target and multi-pathway. The anti-breast cancer effects and molecular mechanisms of Astragali Radix and its active ingredients were reviewed to provide reference for further research and development of new drugs.

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2023年中央财政转移支付地方项目——中药创新能力提升项目（甘财社[2023]53号）;中医药人才培养重点学科建设项目（甘财社[2022]48号）