从天然中草药中提取活性成分已成为治疗骨缺损修复的新方案。小檗碱作为一种异喹啉生物碱，广泛存在于黄连等植物根茎中。近年来研究发现小檗碱可以通过促进成骨细胞的骨形成、抑制破骨细胞的骨吸收、发挥抗菌能力、降低氧化应激反应、调节巨噬细胞的免疫反应减轻炎症等多种途径促进骨缺损修复。据研究报道，小檗碱的促成骨能力已被证实，但具体的作用机制尚未完全阐明。因此，通过整理、分析总结国内外相关文献，对小檗碱治疗骨缺损修复的作用机制、药动学、改良应用等研究进行综述，为小檗碱的开发和临床应用提供理论依据。

Extracting active ingredients from natural Chinese herbal medicines has become a new treatment for bone defect repair. Berberine, as an isoquinoline alkaloid, is widely found in rhizomes of plants such as Coptis chinensis. Recent studies have found that berberine can promote bone defect repair by promoting bone formation of osteoblasts, inhibiting bone resorption of osteoclasts, exerting antibacterial ability, reducing oxidative stress, regulating immune response of macrophages and reducing inflammation. According to research reports, the osteogenic ability of berberine has been confirmed, but the specific mechanism of action has not been fully elucidated. Therefore, through the collation, analysis and summary of relevant literatures at home and abroad, the mechanism of action, pharmacokinetics, and improved application of berberine in the treatment of bone defect repair were reviewed to provide a theoretical basis for the development and clinical application of berberine.

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四川省科技厅项目（2022YFSY0043）;四川省科技厅项目（2022NSFSC1537）;南充市科技局项目（22SXCXTD0001）;南充市科技局项目（22SXQT0382）;四川省大学生创新创业项目（S202310634106）