目的 对药食同源中药抗衰老研究现状和热点进行可视化分析，为今后的深入研究和临床应用提供参考。方法 研究数据来源于中国知网（CNKI）和Web of Science数据库，对数据库自建库起至2024年的文献进行筛选。利用CiteSpace和VOSviewer软件对文献的关键词、作者、机构进行可视化分析。结果 纳入中文文献588篇，英文文献277篇。药食同源中药抗衰老领域发文量呈波动上升的趋势，中英文文献各有60位和59位作者发文量突出，中文文献以吉林农业大学等机构为中心形成紧密合作网络，英文文献中Chinese Academy of Sciences（中国科学院）与Consejo Nacional de Investigaciones Cientificas y Tecnicas（CONICET）等机构发文量位于前列。发文期刊方面，食品工业科技和Journal of Ethnobiology and Ethnomedicine分别在中英文领域发文量领先。中文文献中抗氧化、药理、化学成分和多糖等关键词频繁出现，英文文献则聚焦于药用植物和氧化应激等。聚类和突现分析显示药食同源、桑叶、肠道菌群等为研究热点，英文文献突出抗氧化活性和食物活性成分的作用。共现密度视图显示了抗氧化、多糖、抗衰老等关键词的研究热度。结论 目前药食同源中药抗衰老的研究热点主要集中在分离纯化、药理作用、营养成分、抗氧化、多糖等方面，尚存在团队间缺乏大规模合作、研究深度不够等不足。未来针对具有抗衰老的药食同源中药研究将聚焦于代谢组学、转录组学、肠道菌群等多方面的相互作用。

Objective To provide reference for future in-depth research and clinical application by visualizing and analyzing the current status and hot direction of the research on anti-aging of medicine and food homologous traditional Chinese medicine. Methods Data were retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science databases, covering publications from their inception to 2024. Visualization and analysis of keywords, authors, and institutions in the literature were conducted using CiteSpace and VOSviewer softwares. Results A total of 588 Chinese and 277 English literature were included. The number of publications in the field of anti-aging effects of food and medicinal homologous traditional Chinese medicine has shown a fluctuating upward trend, with 60 and 59 authors in Chinese and English literatures respectively. Chinese literature forms a tightly-knit cooperative network centered around institutions such as Jilin Agricultural University, In the English literature, the number of papers published by institutions such as the Chinese Academy of Sciences and CONICET are at the forefront. In terms of journals, Food Industry Science and Technology andJournal of Ethnobiology and Ethnomedicinelead in the number of articles published in Chinese and English, respectively. Keywords such as antioxidant, pharmacology, chemical composition and polysaccharides frequently appear in Chinese literature, while English literature focuses on medicinal plants and oxidative stress. Cluster and emergence analysis showed that medicine and food homology, mulberry leaves, gut microbiota, etc. were research hotspots, and English literature highlighted the role of antioxidant activity and active ingredients in food. The co-occurrence density view showed the research popularity of keywords such as antioxidant, polysaccharide, and anti-aging. Conclusion Currently, the research hotspots on the anti-aging effects of food and medicinal homologous traditional Chinese medicine mainly focus on isolation and purification, pharmacological effects, nutritional components, antioxidants, polysaccharides, and other related areas. There are still some deficiencies such as the lack of large-scale cooperation between teams, insufficient research depth. In the future, research on food and medicinal homologous traditional Chinese medicines with anti-aging effects will focus on the interactions among metabolome, transcriptome, intestinal flora, and other aspects.

G350;R285

赣江中药创新中心自主部署项目（CMSC32309）;江西省双千项目（jxsq2020101090）