目的 分析半夏-乌头类临床同方使用方剂，探讨其配伍应用规律。方法 检索半夏乌头类临床同方使用文献，纳入相关方剂，构建中药数据库，筛选高频中药并统计高频中药的用量范围和常用量，分析剂型和给药途径、药性（四气、五味、归经、毒性）和功效分类情况，并进行关联规则分析、因子分析和主成分分析及系统聚类分析。结果 纳入处方1 761首。高频中药用量范围广，常用量多为10 g和15 g。运用剂型以汤剂最多，用药途径以内服最多。合用中药的药性中，四气以温、平为主，五味以辛、甘为主，归经以归脾、肺经为主，毒性以无毒为主；功效以补虚药和化痰止咳平喘药为主；得到中药关联组合40组，公因子20个，系统聚类为13个。结论 半夏-乌头类反药组合临床同方使用呈现药性、功效间多维结合，配伍形式为药对、方剂和合方加减，为指导中药十八反的临床安全应用提供一定参考。

Objective To analyze the use pattern of the same clinical formula of Banxia (Pinelliae Rhizoma) and Wutou (Aconitumcarmichaelii) contrary drug combinations, exploring the compatibility application rules among them. Methods Retrieving clinical literature on the use of similar formulas in Pinelliae Rhizoma and A.carmichaelii, including relevant formulas, constructing a Chinese medicine database, screening high-frequency Chinese medicine, and calculating the dosage range and commonly used amount of high-frequency Chinese medicine. Analyzing the dosage form and route of administration, as well as the medicinal properties (four qi, five flavors, meridian tropism, toxicity) and efficacy classification of Chinese medicine. Association rule analysis, factor analysis and principal component analysis, and systematic cluster analysis were carried out. Results A total of 1 761 prescriptions were included. The dosage range of high-frequency traditional Chinese medicine is wide, with commonly used amounts of 10 g and 15 g. The most commonly used dosage form is decoction; The most common route of medication is oral administration. In the medicinal properties of traditional Chinese medicine, the four qi are mainly warm and calm, the five flavors are mainly spicy and sweet, the meridians are mainly spleen and lung meridians, and the toxicity is mainly non-toxic; The classification of efficacy is mainly based on tonifying deficiency drugs and resolving phlegm, stopping cough, and relieving asthma drugs; A total of 40 groups of traditional Chinese medicine association combinations were obtained, with 20 common factors and 13 systematic clusters. Conclusion The clinical use of the same formula in Pinelliae Rhizoma and A.carmichaelii contrary drug combinations of drug properties and effects, and the form of compatibility is the addition or subtraction of drug pairs, prescriptions, and combined prescriptions. The results provide a certain reference for guiding clinical safety applications of eighteen incompatibilities.

R283.6

教育部第三批国家级精品资源共享课建设项目（2013-94）;国家重点基础研究发展计划（973计划）资助项目（2011CB505306）