[关键词]
[摘要]
全球正面临着老龄化带来的巨大挑战，衰老是诸多老龄化疾病的综合体现，心血管衰老既是老年心血管疾病的共同病理基础，又是增龄疾病的独立危险因素。以心血管衰老为新的干预靶标，阐明心血管衰老分子细胞调控网络，对于心血管衰老相关疾病的防治具有重要临床价值。通过梳理不同细胞衰老在心血管衰老中的作用，总结炎性衰老、代谢失灵活性、表观遗传学转变及线粒体功能障碍在心血管衰老中的复杂网络调控机制，概述了中医药干预心血管衰老的药理作用研究进展，为衰老相关心血管疾病治疗提供病证结合思路。
[Key word]
[Abstract]
The world is facing a great challenge brought by aging, and aging is a comprehensive manifestation of many aging diseases. Cardiovascular aging is both the common pathological basis of cardiovascular diseases in the elderly and an independent risk factor for age-increasing diseases. Taking cardiovascular senescence as a new intervention target, elucidating the molecular and cellular regulatory network of cardiovascular senescence is of great clinical value for the prevention and treatment of cardiovascular senescence-related diseases. In this paper, the role of different cellular senescence in cardiovascular aging was sorted out, the complex network regulatory mechanisms of inflammatory aging, metabolic inflexibility, epigenetic transition and mitochondrial dysfunction in cardiovascular aging were summarized, and the pharmacological research results of traditional Chinese medicine in intervening in cardiovascular aging were outlined, with a view to providing a combination of pathology and evidence for the treatment of aging-related cardiovascular diseases.
[中图分类号]
R285
[基金项目]
中国中医科学院西苑医院中医药临床循证证据提升专项-揭榜挂帅项目(XYZX0204-04);中国博士后科学基金项目(2023M733915);国家中医药管理局中医药传承与创新"百千万"人才工程-岐黄学者项目(02045006);国家中医药管理局中医药循证能力建设项目(ZZ13-024-4)
