抑郁症是一种常见的精神疾病，其发病机制至今尚未完全阐明。近年来，5-羟色胺（5-hydroxytryptamine，5-HT）与缝隙连接的交互作用在抑郁症发病中的关键作用逐渐受到关注。通过总结关于5-HT和抑郁症的现有发现、缝隙连接与抑郁症的关系、中药调控5-HT和缝隙连接相关机制的研究进展，对当前关于5-HT与缝隙连接在抑郁症发病过程中的交互作用的研究进展进行综述，为进一步探索抑郁症的发病机制提供有益参考。

Depression is a common mental illness, and its pathogenesis has not been fully elucidated. In recent years, the key role of the interaction between 5-hydroxytryptamine (5-HT) and gap junction in the pathogenesis of depression has been gradually paid attention. By summarizing the existing findings on 5-HT and depression, the relationship between gap junction and depression, and the research progress on the mechanism related to the regulation of 5-HT and gap junction by traditional Chinese medicine, the current research progress on the interaction between 5-HT and gap junction in the pathogenesis of depression was reviewed, providing a useful reference for further exploration of the pathogenesis of depression.

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国家自然科学基金资助项目(82304750);国家自然科学基金资助项目(82130109);国家自然科学基金资助项目(U2202214);湖南省自然科学基金(2022JJ40313,2021JJ30512);湖南省教育厅科研基金优秀青年项目(22B0352);湖南省中医药管理局科研基金(B2023139);湖南中医药大学科研项目(2021XJJJ028)