西红花Croci Stigma为鸢尾科番红花属植物的干燥柱头，其主要化学成分包括萜类、黄酮类、蒽醌类、多取代单苯环类、环己烷和环己烯衍生物、氨基酸及生物碱类、呋喃类等，具有活血化瘀、凉血解毒、解郁安神之效。近年来，西红花及其活性成分在抑郁症和肝脏疾病治疗方面的应用较多，但其物质基础和作用机制尚缺乏系统的总结。通过对西红花及其活性成分的抗抑郁和保肝作用的药效物质基础及作用机制进行综述，为西红花治疗肝脏疾病和抑郁症的深入研究及临床进一步的开发利用提供科学的参考。

Xihonghua (Croci Stigma) is the dry stigma of Crocus sativus in Iris family. Its main chemical components include terpenoids, flavonoids, anthraquinones, multi-substituted mono benzenes, cyclohexane and cyclohexene derivatives, amino acids and alkaloids, furans, etc. It has the effects of promoting blood circulation and removing blood stasis, cooling blood and detoxification, relieving depression, and tranquilizing the mind. In recent years, Croci Stigma and its active ingredients have been more and more used in treatment of liver disease and depression. However, its material basis and mechanism of action are still lacking of systematic summary. In this study, the pharmacodynamic material basis and mechanism of the anti-depression and hepatoprotective effects of Croci Stigma and its active ingredients in recent years have been reviewed. It is expected to provide a scientific reference for the in-depth study and further utilization of Croci Stigma in treatment of liver diseases and depression.

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浙江省领雁项目(2022C03050);金华市科技项目(2020-1-025);文成县科技项目(2021NKY04)