中医药是一种多成分、多靶点、多通路的医学体系，拥有丰富疗法，但很多明确疗效的中药至今仍无法明确其药效物质基础和作用机制。外泌体是细胞主动分泌的磷脂双层囊泡，具有保护药物在血液循环中不被细胞吞噬或系统清除等特性，可作为递送载体，并在免疫反应、信号转导等细胞过程中发挥重要作用。外泌体作为中药单体递送系统和中医药通过调控外泌体治疗疾病近年来已成为中医药领域研究热点，以外泌体为切入点，旨在阐明中医药发挥疗效的微观作用机制，推动外泌体在中医药领域中发展和应用。

a multi-component, multi-target, multi-pathway medical system with rich therapies, but many of the clear efficacy of TCM is still unable to clarify its drug substance basis and mechanism of action. Exosomes are phospholipid bilayer vesicles that are actively secreted by cells and have the ability to protect drugs from being phagocytized by cells or systematically eliminated in the bloodstream. They can be used as delivery vehicles and play an important role in cellular processes such as immune response and signal transduction. Exosomes as a delivery system for TCM monomers and Chinese medicine treatment of diseases by regulating exosomes have become hot research topics in TCM field in recent years. This study takes exosomes as an entry point to elucidate the micro-mechanism of the therapeutic effect of TCM and promote the development and application of exosomes in the field of TCM.

R285

山东省"中医药+"新产品研发推广项目;山东省重大科技创新工程项目(2019JZZY020906);山东省青创团队;山东省中药制剂重点实验室