糖尿病是一种由多病因引起的以慢性高血糖为特征的代谢性疾病，由于胰岛素分泌和（或）利用缺陷所导致。糖尿病临床常见并发症包括糖尿病肾病、糖尿病视网膜病变、糖尿病性心肌病等。糖尿病及其相关并发症的发生发展与细胞焦亡关系密切。细胞焦亡作为一种程序性细胞死亡方式，在炎症反应和相关疾病的发生发展中起着重要作用。通过阐述糖尿病及其并发症与细胞焦亡之间的关系，总结中药活性成分及中药复方干预细胞焦亡治疗糖尿病及其相关并发症的最新研究进展，为糖尿病及其并发症的发病机制和药物治疗的深入研究提供新思路，进一步探寻具有调节炎症小体和细胞焦亡的潜在治疗药物，为临床运用中医药防治糖尿病及其相关并发症提供依据。

Diabetes mellitus (DM) is a multi-etiological metabolic disease characterized by chronic hyperglycemia, resulting from deficiencies in insulin secretion and/or utilization. The common clinical complications of DM include diabetic nephropathy, diabetic retinopathy and diabetic cardiomyopathy. The occurrence and development of DM and its related complications are closely related to pyroptosis. As a programmed cell death mode, pyroptosis plays an important role in the occurrence and development of inflammation and related diseases. By describing the relationship between DM and its complications and pyroptosis, this paper summarized the latest research progress of traditional Chinese medicine active ingredients and traditional Chinese medicine compounds intervention in the treatment of DM and its related complications, providing new ideas for the in-depth study of the pathogenesis and drug therapy of DM and its complications. To further explore potential therapeutic drugs that can regulate inflammasome and pyroptosis, and provide a basis for the clinical use of traditional Chinese medicine to prevent and treat DM and its related complications.

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国家中医药领军人才支持计划——岐黄学者([2018] 12);辽宁省科技厅——辽宁省糖尿病中医病证结合重点实验室(2019JH6/10100009);辽宁省教育厅校际合作项目(2100221206);辽宁省应用基础研究计划项目(20230319)