[关键词]
[摘要]
目的 对河口五层龙Salacia obovatilimba石油醚部分进行化学成分研究。方法 采用硅胶柱色谱、MCI、Sephadex LH-20柱色谱和半制备型高效液相色谱等分离手段进行分离纯化，根据理化性质和现代波谱技术对化合物结构进行鉴定。结果 从河口五层龙枝叶90%乙醇提取物的石油醚萃取部分分离得到8个化合物，分别鉴定为22β,28-dihydroxyfriedelan-3-one（1）、22β-hydroxyfriedelan-3-one（2）、乌苏酸（3）、28-hydroxyfriedelan-3-one（4）、22β-hydroxyfriedel-1-ene（5）、β-cyclocostunolide（6）、methyl 4-hydroxybenzoate（7）、4,6-dihydroxy-2-methoxyacetophenone（8）。结论 化合物1、2为新木栓烷型三萜，命名为河口五层龙醇A、河口五层龙醇B。所有化合均为首次从河口五层龙中分离得到；除化合物3、4外，其余化合物均为首次从五层龙属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of the petroleum ether extract of Salacia obovatilimba. Methods The chemical constituents of the petroleum ether fraction from 90% ethanol extract of S. obovatilimba branches and leaves was investigated by silica gel, MCI, Sephadex LH-20 and semi-preparative high performance liquid chromatography, the structural identification of the isolates were carried out by spectroscopic analysis. Results Eight compounds were obtained from the petroleum ether extract of S. obovatilimba. Their structures were identified as 22β,28-dihydroxyfriedelan-3-one (1), 22β-hydroxyfriedelan-3-one (2), ursolic acid (3), 28-hydroxyfriedelan-3-one (4), 22β-hydroxyfriedel-1-ene (5), β-cyclocostunolide (6), methyl 4-hydroxybenzoate (7), and 4,6-dihydroxy-2-methoxyacetophenone (8). Conclusion Compounds 1 and 2 were new friedelane triterpenoids named obovatilinol A and obovatilinol B. All compounds were firstly isolated from S. obovatilimba, and compounds 1, 2, 5―8 were isolated from the plants of Salacia genus for the first time.
[中图分类号]
R284.1
[基金项目]
国家自然科学基金项目(82360688);云南省中医药联合专项重点项目(202101AZ070001-164);云南省教育厅高原特色民族药用植物研究科技创新团队;国家中医药管理局高水平中医药重点学科建设项目-傣药学(Zyyzdxk-2023192)
