外泌体是一种直径为30～150 nm的细胞外囊泡，在调节细胞间通讯和影响多种疾病进展方面具有重要作用。柑橘属植物来源的外泌体样纳米颗粒在物理性质和组成成分上类似于哺乳动物来源的外泌体，具有抗肿瘤、抗氧化和抗炎等药理作用，还可以作为药物递送载体，在疾病治疗中展现出广泛的应用前景。通过检索中国知网和Web of Science等数据库，对柑橘属植物来源的外泌体样纳米颗粒在制备、表征、稳定性、转运与分布、药理作用及药物载体应用的研究进展进行综述，为柑橘属植物来源的外泌体样纳米颗粒进一步开发利用提供参考。

Exosomes, small extracellular vesicles ranging in size from 30—150 nm and serve as key modulators of intercellular communication and play vital roles in the progression of numerous diseases. Citrus-derived exosome-like nanoparticles possess the same physical properties and compositional features as those of exosomes from mammalian cells, exhibit multiple pharmacological effects such as anti-tumor, antioxidant, and anti-inflammatory properties and are used as delivery carrier, which has a wide range of application prospects in the treatment of various diseases. By searching CNKI, Web of Science and other databases, the research progress of Citrus-derived exosome-like nanoparticles in preparation, characterization, stability, transportation and distribution, pharmacological actions along with drug delivery were reviewed, so as to provide reference for the further development and utilization of Citrus-derived exosome-like nanoparticles.

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国家自然科学基金资助项目(82030116);天津市科技计划项目(23ZYJDSS00010)