[关键词]
[摘要]
类风湿关节炎作为一种临床常见的致残性慢性自身免疫疾病,近年来关于民族医药治疗类风湿关节炎的研究越来越多。部分研究表明民族医药通过调控炎性反应、调节免疫细胞、抗血管新生、促进成纤维样滑膜细胞凋亡、维持关节软骨及骨细胞内平衡以治疗类风湿关节炎,其多途径、多靶点的显著的优势备受关注。通过对近年来民族医药治疗类风湿关节炎的基础研究新进展进行综述,为该病的基础研究、新药研发提供借鉴。
[Key word]
[Abstract]
Rheumatoid arthritis is a common and clinically disabling chronic autoimmune disease. In recent years, there has been an increasing number of studies on the treatment of rheumatoid arthritis with ethnic medicine. Some studies have shown that ethnic medicine treats rheumatoid arthritis by modulating inflammatory response, regulating immune cells, anti-angiogenesis, promoting apoptosis of fibroblast-like synoviocytes, and maintaining intracellular homeostasis of articular cartilage and bone cells. Its remarkable advantages of multiple pathways and targets have attracted much attention. This article reviews the recent progress of the basic research on the treatment of rheumatoid arthritis by ethnic medicine in order to provide some new insights for basic research and new drug development of rheumatoid arthritis.
[中图分类号]
R285
[基金项目]
国家重点研发计划项目(2018YFC1705201);天津市南开区中医药传承创新发展示范点项目(NKQPT2024008);国家中医药管理局中医药重点学科能力提升项目中医痹病学(2018ZDXK001);中医药传承与创新“百千万”人才工程(岐黄工程)(中医药人民教育函 [2018] 12号);全国名老中医药专家传承工作室(975022)