在人体中，对蛋白质组进行系统性研究是充分了解生物过程的必要条件。关节炎是目前最常见的全身性炎症之一，其主要诊断依据为临床症状、影像学或一些常规的检验及检查结果。这些方法对于诊断急性发作期及慢性期的关节炎较为有效，但在评估和监测关节炎病程发展的方面具有一定局限性。因此，寻找可用于关节炎早期诊断与全程监测的生物标志物成为当前临床研究领域中亟待解决的问题。而蛋白质组学能够从整体上分析蛋白质的组成、结构及其功能，从而发现具有较高特异性及灵敏度的生物标记物，加深对关节炎发病机制和病程进展的认识。通过对近年来国内外基于蛋白质组学在关节炎领域筛选生物标志物的研究进行综述，并就其在关节炎诊疗中的功能及意义进行概述，为关节炎的临床诊疗研究提供参考。

In the human body, a systematic study of proteomes is a necessary condition for a full understanding of biological processes. Arthritis is one of the most common systemic inflammation at present. Its primary diagnosis is based on clinical symptoms, imaging or some routine tests and examination results. These methods are effective in the diagnosis of acute and chronic arthritis, but have certain limitations in evaluating and monitoring the development of arthritis. Therefore, finding biomarkers that can be used for early diagnosis and whole-course monitoring of arthritis has become an urgent problem to be solved in the current clinical research field. Proteomics can analyze the composition, structure and function of proteins as a whole, so as to find biomarkers with high specificity and sensitivity, and to deepen understanding of the pathogenesis and progression of arthritis. This paper reviews the research on the screening of biomarkers in the field of arthritis based on proteomics in recent years, and summarizes its function and significance in the diagnosis and treatment of arthritis, so as to provide reference for the clinical diagnosis and treatment of arthritis.

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国家自然科学基金资助项目（82204590）;江西省自然科学基金资助项目（20224BAB216099）;中国博士后科学基金第七十三批面上资助（2023M731439）;江西省研究生创新专项资金项目（YC2023-S789）