目的 基于中英文数据库对中西医治疗射血分数保留的心力衰竭（heart failure with preserved ejection fraction，HFpEF）相关文献的研究现状进行分析，并进一步探讨研究热点及趋势，为HFpEF诊疗方案的创新及未来研究方向提供参考。方法 检索2000年1月1日—2024年3月1日国内外数据库中收录的HFpEF治疗相关的文献，采用VOSviewer 1.6.20、CiteSpace 6.3.R1及借助R4.3.3运行的Bibliometrix文献计量学工具进行分析，对发文量、国家、机构、期刊引文、作者及关键词等方面进行可视化展示，并解读其内涵。结果 共纳入中文文献2 968篇，英文文献3 569篇，发文均呈现上升趋势，中英文发文量最多的机构分别是中国中医科学院西苑医院及哈佛大学，国内作者及团队发表研究数量较少，合作稀疏。中医治疗HFpEF研究侧重病因病机理论研究、用药经验总结、中医证型研究及中西医结合治疗等方向，在具体治疗上侧重运用中药汤剂联合中成药、中药注射剂及化学药促进HFpEF患者健康的恢复。西医相关研究聚焦于药物临床试验及疾病病理生理机制的探讨，其多采用药物干预及运动训练等干预措施进行治疗。结论 目前HFpEF治疗的研究热度持续增加，中西医治疗存在着较大的差异，未来应在中医整体观念及辨证论治的指导下，挖掘出临床有效方药，采用中西医结合的综合疗法对HFpEF患者进行早期干预。

Objective To analyze the current research status of the articles related to the treatment of heart failure with preserved ejection fraction (HFpEF) based on Chinese and English databases, and to further explore the respective research hotspots and trends in the treatment of HFpEF using traditional Chinese and western medicines. This study aims to provide references for the innovation of diagnostic and therapeutic protocols for HFpEF and guide researchers in selecting future research directions. Methods The literature related to the treatment of HFpEF from domestic and international databases between January 1, 2000, and March 1, 2024, was searched and analyzed using VOSviewer 1.6.20, CiteSpace 6.3.R1, and the Bibliometrix supported by the R language. This analysis aimed to analyze the number of publications, national institutions, journal citations, authors, and keywords for visualization and interpretation. Results A total of 2 968 articles in Chinese and 3 569 articles in English were included, all displaying an upward trend in publication. The institutions with the highest publication rates were Xiyuan Hospital of China Academy of Chinese Medical Sciences and Harvard University, respectively. The number of studies published by various authors and teams in China was relatively low, with sparse collaboration. Research on traditional Chinese medicine (TCM) treatment of HFpEF focuses on theories of etiology and pathogenesis, summarization of medication experience, study of TCM patterns, and combination of TCM and western medicine, etc. Specific treatment focuses on the use of decoction in combination with Chinese patent medicine, TCM injections, and western medicines to promote patient recovery from HFpEF. Western medicine research focuses on clinical trials of drugs and exploration of the pathophysiological mechanisms, and most of the interventions used are pharmacological interventions and exercise training. Conclusion The current research fervor for HFpEF treatment continues to increase. Significant disparities exist between traditional Chinese and western medical treatments. Moving forward, under the guidance of the holism concept and treatment based on syndrome differentiation in TCM, efforts should be made to identify clinically effective formulas. Implementing comprehensive therapies that integrate traditional Chinese and western medicine is crucial for early intervention in HFpEF patients.

G350;R285.64

国家自然科学基金面上项目（82274436）;国家中医药多学科交叉创新团队项目（ZYYCXTD-D-202207）