目的 探究冰片产业的研究热点与前沿动态，为冰片后续研究创新及产业高质量发展提供可视化依据。方法 收集整理中国知网（CNKI）与Web of Science（WOS）核心数据库中冰片的相关文献，利用CiteSpace软件分别对中英文文献的发文量、作者、发文机构、关键词进行可视化处理，并结合可视化图谱分析各热点前沿主题在中英文文献中的分布特征与差异。结果 检索到中文文献3 515篇，英文文献1 718篇。发文较活跃的作者为王建、郑晓晖、Salakhutdinov Nariman F，中国科学院、成都中医药大学、广州中医药大学和俄罗斯科学院（Russian Academy of Sciences）是目前的主要研究机构。关键词分析显示，近20年来国内外的研究热点主要集中在冰片对血脑屏障通透性的影响及促透作用，中文文献多以中医药理论与文化为背景，研究冰片的引药上行作用以及含冰片中药制剂的质量控制等，英文文献则更多探究冰片来源植物的分子机制、冰片衍生物的合成，以及冰片和富含冰片精油的成分分析与生物活性。结论 目前冰片产业正处在备受关注的快速发展阶段，研究人员在未来应当基于中医药理论与临床实践，结合前沿科技探明冰片透过血脑屏障的调控机制，加强龙脑樟的靶向改良和精油开发，并利用人工智能技术赋能中医药传承创新，深挖中医药大数据，推动冰片新药研发，走多学科、多方向、多途径开发的道路，突破制约发展的瓶颈问题，切实推进冰片全产业链高质量发展。

Objective To investigate the research hotspots and frontier trends of the borneol industry and to provide a visual basis for subsequent research innovation and high-quality industrial development of borneol. Methods Collect and organize relevant literature on borneol from the China National Knowledge Infrastructure (CNKI) and the Web of Science (WOS) core databases. Use CiteSpace software to perform visual processing of the publication volume, authors, publishing institutions, and keywords of Chinese and English literature. Furthermore, analyze the distribution characteristics and differences of various hot frontier themes in Chinese and English literature through the visual maps. Results A total of 3 515 Chinese articles and 1 718 English articles were retrieved. the more active authors in publishing are Wang Jian, Zheng Xiaohui, and Nariman F. Salakhutdinov. The Chinese Academy of Sciences, Chengdu University of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, and the Russian Academy of Sciences are currently the main research institutions. keyword analysis shows that the research hotspots at home and abroad in the past 20 years mainly focus on the effect of ice tablets on the permeability of the blood-brain barrier and the effect of promoting permeability. Chinese literature often revolves around traditional Chinese medicine theories and culture, researching the ascending drug-guiding action of borneol and the quality control of traditional Chinese medicine formulations containing borneol. In contrast, English literature explores more on the molecular mechanisms of plants that are sources of borneol, the synthesis of borneol derivatives, and the analysis and biological activity of components rich in borneol essential oil. Conclusion The current stage of the Chinese medicine borneol industry is marked by rapid development and heightened attention. For future research, it is imperative for researchers to base their work on traditional Chinese medicine theories and clinical practices. They should aim to elucidate the regulatory mechanisms of borneol crossing the blood-brain barrier, integrating cutting-edge technologies. Efforts should be made to enhance targeted improvements in Cinnamomum camphora chvar. Borneol and the development of essential oils. Additionally, leveraging artificial intelligence technology can empower the inheritance and innovation of traditional Chinese medicine, delve into the vast data of Chinese medicine, and promote the research and development of new borneol-based drugs. It is crucial to pursue a multidisciplinary, multi-directional, and multi-pathway development approach, break through the bottlenecks restricting growth, and earnestly advance the high-quality development of the entire borneol industry chain.

R282

国家自然科学基金项目（81874344）;湖南省重点领域研发计划（2023SK2046）;湖南省自然科学基金项目（2023JJ60474）;长沙市自然科学基金项目（kq2208191）;湖南创新型省份建设专项（2023NK4110）;湖南省科技创新计划项目（2023NK4144）;湖南中医药大学研究生创新课题（2023CX145）