[关键词]
[摘要]
心肌缺血再灌注损伤（myocardial ischemia reperfusion injury，MIRI）是心梗后血流恢复再灌注诱发的一种疾病，以心肌细胞坏死、凋亡、线粒体功能障碍为主要病理特征，可能出现心肌顿抑、再灌注性心律失常和再发心绞痛等症状。线粒体是细胞代谢的基石，而线粒体质量控制系统（mitochondrial quality control，MQC）是线粒体内环境稳态的根基，也是反映线粒体质量的一个网络系统，对于监测和维持线粒体内环境稳态至关重要。而MQC紊乱可能导致MIRI。近年来，中医药疗法可通过多途径、多靶点、多层次显著改善MIRI。通过对中医药基于MQC治疗MIRI的研究进展进行梳理，为中医药治疗MIRI相关基础研究的转化以及拓展临床思路提供借鉴。
[Key word]
[Abstract]
Myocardial ischemia reperfusion injury (MIRI) is a disease induced by blood flow recovery and reperfusion after myocardial infarction, which is mainly characterized by myocardial cell necrosis, apoptosis and mitochondrial dysfunction. Symptoms such as myocardial stunning, reperfusion arrhythmias, and recurrent angina may occur. Mitochondria are the cornerstone of cell metabolism, and mitochondrial quality control (MQC) system is the foundation of mitochondrial homeostasis, is also a network system, reflect the quality of mitochondria and is vital for monitoring and maintenance of mitochondrial homeostasis. However, MQC disorder may lead to MIRI. In recent years, traditional Chinese medicine (TCM) therapy can significantly improve MIRI through multi-pathways, multi-targets and multi-levels. By summarizing the research progress of TCM therapy in the treatment of MIRI based on MQC, this study provides a reference for the transformation of basic research related to TCM therapy in the treatment of MIRI as well as the expansion of clinical thinking.
[中图分类号]
R285
[基金项目]
国家重点研发计划资助项目（2018YFC1704204）；名中医赵明君传承工作室建设项目（2019007）；陕西省教育厅重点实验室项目（22JS005）；陕西省教育厅专项科研计划（21JK0606）；咸阳市重点研发计划项目（L2023-ZDYF-SF-047）
