目的 研究东京银背藤Argyreia pierreana的化学成分及其抗炎活性。方法 运用硅胶、SephadexLH-20、C₁₈等柱色谱和半制备高效液相色谱对其化学成分进行分离纯化，根据MS、1D/2D NMR等波谱技术确定化合物结构。采用Griess试剂法测试化合物抗炎活性。结果 从东京银背藤中分离得到13个化合物，分别鉴定为8-羟基-1,9-二甲氧基-[2′,2′-二甲基吡喃(5′,6′:2,3)]香豆酮并色酮（1）、derrusin（2）、东莨菪内酯（3）、caesalpiniaphenol D（4）、(−)-gynuraone（5）、咖啡酸甲酯（6）、咖啡酸乙酯（7）、阿魏酸乙酯（8）、反式对羟基肉桂酸乙酯（9）、对羟基苯甲酸（10）、香草酸（11）、咖啡酸（12）、阿魏酸（13）。结论 化合物1为新的苯并呋喃[3,2-c]香豆素类化合物，命名为银背藤内酯（argypierstan），化合物2、4～6、8～13为首次从东京银背藤分离得到。化合物4、6、8和9具有较好的抗炎活性，半数抑制浓度（half maximal inhibitory concentration，IC₅₀）分别为（43.38±0.44）、（4.95±0.10）、（35.96±0.31）、（42.77±1.80）μmol/L。

Objective To study the chemical components and their anti-inflammatory activities in Argyreia pierreana. Methods The chemical components were isolated and purified using methods including silica gel, Sephadex LH-20, C₁₈ column chromatography and semi-preparative high performance liquid chromatography. The structures of the compounds were identified by MS, 1D/2D NMR spectral data and other techniques. The anti-inflammatory activities of the compounds were determined by Griess method. Results A total of thirteen compounds were isolated from A. pierreana, and their structures were identified as 8-hydroxy-1,9-dimethoxy-[2′,2′-dimethylpyrano(5′,6′:2,3)]coumaronochromone (1), derrusin (2), scopoletin (3), caesalpiniaphenol D (4), (-)-gynuraone (5), methyl caffeate (6), ethyl caffeate (7), ethyl ferulate (8), trans-p-hydroxycinnamic acid ethyl ester (9), p-hydroxy benzoic (10), vanillic acid (11), caffeic acid (12), ferulic acid (13). Conclusion Compounds 1 was a new coumarin compound of benzofuran [3,2-c] and named as argypierstan. Compounds 2, 4—6, 8—13 were isolated from A. pierreana for the first time. Compounds 4, 6, 8 and 9 exhibited mild anti-inflammatory activity and the half maximal inhibitory concentration (IC₅₀) was (43.38 ± 0.44), (4.95 ± 0.10), (35.96 ± 0.31) and (42.77 ± 1.80) μmol/L, respectively.

R284.1

广西科技基地和人才专项（桂科AD20159007）；广西中医药大学桂派中医药传承创新团队资助项目（2022B005）；2022年自治区中药学研究生联合培养基地开放项目（桂学位〔2021〕6号）；2022年大学生创新创业训练计划项目（S202210600051）；2021年大学生创新创业训练计划项目（S202110600113）