糖尿病周围神经病变（diabetic peripheral neuropathy，DPN）是指糖尿病患者出现周围神经功能障碍相关症状的慢性并发症，是足部溃疡、感染和截肢的高危因素。临床主要采用疼痛管理、控制血糖和营养神经的药物治疗，多产生耐药性和不良反应，治疗效果并不理想。研究发现黄芪桂枝五物汤（Huangqi Guizhi Wuwu Decoction，HGD）在防治DPN方面具有较好的效果，通过对HGD治疗DPN的药效基础、临床应用及相关作用机制进行综述，为HGD治疗DPN的进一步开发利用提供理论依据和参考。

Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes mellitus in which patients develop symptoms related to peripheral nerve dysfunction, and it is a high-risk factor for foot ulcers, infections and amputations. Clinical treatments mainly use pain management, blood glucose control and nutritive nerve medications, which mostly produce drug resistance and adverse reactions, and the therapeutic effect is not satisfactory. Huangqi Guizhi Wuwu Decoction (黄芪桂枝五物汤, HGD) was found to have better effect in preventing and treating DPN. By reviewing the pharmacodynamic basis, clinical application and related mechanism of action of HGD in treating DPN, it will provide theoretical basis and reference for further development and utilization of HGD in treating DPN.

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山东省自然科学基金项目（ZR2020KH003）；济南市高校院所创新团队项目（2020GXRC012）；山东中医药大学青年创新团队项目（2020-54-19）