目的 对近年来雷公藤红素相关研究现状及研究热点进行可视化分析，为今后该领域的研究和理论发展提供建设性的参考。方法 检索中国知网（CNKI）和Web of Science（WOS）自2000年1月1日—2023年6月30日发表的雷公藤红素的相关文献，应用CiteSpace 6.1.R4软件对作者、机构合作网络，关键词共现、聚类、突现、时间线以及高被引文献进行可视化分析。结果 与雷公藤红素相关的文献检索结果分别纳入674和1 147篇中、英文文献，发文量总体呈阶梯式上升趋势。中文核心作者为张振海、陈彦、瞿鼎，外文核心作者为Gao Wei、Su Ping、Huang Luqi；国内外机构合作较为频繁，关于雷公藤红素的国内外研究主要集中在药理作用、给药系统、生物合成等方面。结论 雷公藤红素近20年来研究热度不断上升，抗肿瘤、抗炎、抗肥胖等药理作用成为雷公藤红素的主流研究热点，给药系统、生物合成等将是雷公藤红素未来新的研究方向。

Objective To analyze and visualize the research status and hotspots related to celastrol in recent, and provide constructive reference for future research and theoretical development in this field. Methods Searching the literature related to celastrol published on China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) from January 1, 2000 to June 30, 2023, and CiteSpace 6.1.R4 software was applied to visualise and analyse the authors, institutional collaborative networks, keyword co-occurrences, clustering, bursting, timeline, and highly cited literature. Results The results of the literature search related to celastrol included 674 and 1147 Chinese and English literature, respectively, and the number of publications generally showed a stepped-up trend. The Chinese core authors are Zhang Zhenhai, Chen Yan, and Qu Ding, and the foreign core authors are Gao Wei, Su Ping, and Huang Luqi. Cooperation between domestic and foreign institutions was more frequent. Researches on celastrol at home and abroad mainly focus on pharmacological effects, drug delivery systems and biosynthesis. Conclusion In the past 20 years, the research heat on celastrol has been increasing, antitumour, anti-inflammatory, anti-obesity and other pharmacological effects have become the mainstream research hotspots of celastrol, and the drug delivery system and biosynthesis will be the new research direction of celastrol in the future.

G350；R284

国家自然科学基金项目（82204552）；中国博士后科学基金项目（2021M692893）；浙江省中医药科技计划项目（2023ZR079）；浙江省大学生新苗人才计划（2023R410043）