目的 研究川西合耳菊Synotis solidaginea的化学成分。方法 采用硅胶、聚酰胺、反相C₁₈柱色谱及制备高效液相色谱等技术进行分离纯化；根据波谱数据和文献对比进行化合物结构鉴定。结果 从川西合耳菊的醋酸乙酯萃取部位共分离得到18个化合物，分别鉴定为 (2R,4S,5R,8R,10S)-2-angeloyloxy-8,10-dihydroxy-eremophil-7(11)-en-8,12-olide（1）、(1R,4S,5S, 6S,8R,10S)-1,10-epoxy-6,8-dihydroxy-eremophil-7(11)-en-8,12-olide（2）、(4S,5R,8S,10S)-8,10-dihydroxy-eremophil-7(11)-en- 8,12-olide（3）、(4S,5R,8R,10S)-10-hydroxy-eremophil-7(11)-en-8,12-olide（4）、橐吾内酯（5）、4,5-O-二咖啡酰奎宁酸甲酯（6）、异绿原酸C（7）、3,5-O-二咖啡酰基奎宁酸甲酯（8）、异绿原酸A（9）、1,4-O-二咖啡酰奎宁酸甲酯（10）、绿原酸（11）、咖啡酰苹果酸（12）、咖啡酸甲酯（13）、反式咖啡酸（14）、山柰酚-3-O-(6''-O-乙酰基)-β-D-吡喃葡萄糖苷（15）、紫云英苷（16）、2-苯乙基-β-D-吡喃葡萄糖苷（17）、桦褐孔菌二糖（18）。结论 化合物1为新的艾里莫芬烷倍半萜类化合物，命名为川西合耳菊内酯A；化合物2、4、5、10、12、13、15、17、18为首次从合耳菊属中分离得到。

Objective To study the chemical constituents from the plant of Synotis solidaginea. Methods The extract of S. solidaginea was isolated and purified by silica gel, polyamide, C₁₈ reversed-phase silica gel, and preparative HPLC. Their structures were identified by comparison of spectral data and literature. Results A total of 18 compounds were isolated from the ethyl acetate extract of S. solidaginea and identified as (2R,4S,5R,8R,10S)-2-angeloyloxy-8,10-dihydroxy-eremophil-7(11)-en-8,12-olide (1), (1R,4S,5S, 6S,8R,10S)-1,10-epoxy-6,8-dihydroxy-eremophil-7(11)-en-8,12-olide (2), (4S,5R,8S,10S)-8,10-dihydroxy-eremophil- 7(11)-en-8,12-olide (3), (4S,5R,8R,10S)-10-hydroxy-eremophil-7(11)-en-8,12-olide (4), (4S,5R)-eremophil-1(10),7(11),8(9)-trien- 8,12-olide (5), 4,5-di-O-caffeoylquinic acid methyl ester (6), 4,5-di-caffeoylquinic acid (7), 3,5-di-O-caffeoylquinic acid methyl ester (8), 3,5-di-caffeoylquinic acid (9), 1,4-di-O-caffeoylquinic acid methyl ester (10), chlorogenic acid (11), (2'R)-phaselic acid (12), caffeic acid methyl ester (13), trans caffeic acid (14), kaempferol-3-O-(6''-O-acetyl)-β-D-glucopyranoside (15), astragalin (16), 2-phenylethyl-β-D-glucopyranoside (17), inotodisaccharide (18). Conclusion Compound 1 was a new eremophilane-type sesquiterpenoid and named synotisolidolide A, while compounds 2, 4, 5, 10, 12, 13, 15, 17 and 18 were isolated from the genus Synotis for the first time.

R284.1

四川省药品监督管理局中药（民族药）标准提升项目（510201201904914）；四川省高校科研创新团队建设计划项目（18TD0017）