阿尔茨海默病(Alzheimer's disease,AD)是一种与年龄相关的神经退行性疾病,主要表现为进行性认知功能的减退以及记忆障碍。随着我国人口老龄化速度的加快,AD的患病人数也在不断增加。此外,由于AD发病机制的不确定性,导致目前缺乏有效的治疗手段,使AD逐渐成为严重影响老年人身心健康重要原因之一。近年来研究表明,中药复方的多途径、多靶点等机制对防治AD具有明显价值和优势。补阳还五汤作为中医经典名方,被认为具有潜在的改善AD作用。通过对近年来补阳还五汤及其组分改善AD病理和症状相关机制研究进行综述,为补阳还五汤AD的临床应用和实验研究提供理论基础和研究思路。

Alzheimer's disease (AD) is an age-related neurodegenerative disease, which is characterized by progressive cognitive decline and memory impairment. With the acceleration of population aging in China, the number of patients with AD is also increasing. In addition, due to the uncertainty of the pathogenesis of AD, there is still a lack of effective treatment, which has gradually became one of the important reasons that seriously affects the physical and mental health of the elderly. In recent years, studies have shown that the multi-channel and multi-target mechanism of traditional Chinese medicine compound has obvious value and advantages in preventing and treating AD. Buyanghuanwu Decoction (补阳还五汤), as a classic prescription of traditional Chinese medicine, is considered to have the potential effect of improving AD. In this paper, the mechanism of Buyanghuanwu Decoction and its components in improving the pathology and symptoms of AD in recent years is reviewed, which provides theoretical basis and research ideas for the clinical application and experimental research of Buyanghuanwu Decoction in the future.

黑龙江省中医药管理局课题（ZHY202087）；黑龙江中医药大学校基金项目（2017xy）