目的 进一步研究三七Panax notoginseng干燥根的化学成分。方法 采用大孔吸附树脂、硅胶柱、C₁₈反相硅胶柱、Sephadex LH-20凝胶等方法进行成分分离,再依据理化性质和波谱数据对化合物进行结构鉴定。结果 从三七干燥根70%乙醇提取物中分离得到11个化合物,包括萜类5个、吡喃酮类3个、呋喃酮类1个、酚苷类1个、其他类1个,分别鉴定为(S)-2-乙基-6-羟基-7-甲氧基苯酞-6-α-L-鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(1)、△⁸⁽⁹⁾-(Z)-(R)-6-(1-羟基己基)-4-甲氧基-2(5H)-吡喃酮(2)、6-(1-羟基戊基)-4-甲氧基-2(5H)-吡喃酮(3)、6-(1-羟基己基)-5-羟基-3-甲氧基-2(5H)-吡喃酮(4)、4β,10α-香木兰烷二醇(5)、异胡萝卜-6-烯-10β,14-二醇(6)、4(15)-桉叶烯-1β,6α-二醇(7)、两面针碱D(8)、两面针碱C(9)、5-(1-羟基庚基)-3-甲氧基-2(5H)-呋喃酮(10)、3E-5-甲氧基-6-羟基-6-甲基-3-庚烯-2-酮(11)。结论 化合物1、2为新化合物,分别命名为三七酚酞苷和三七己烯吡喃酮。化合物6、8、9、11为首次从该植物中分离。

Objective To study the chemical constituents of the dried roots of Sanqi[Panax notoginseng (Burk.) F. H. Chen]. Methods The separation of the components was carried out using macroporous adsorbent resin, silica gel column, C₁₈ reversed-phase silica gel column, and Sephadex LH-20 gel. The structures were identified by physicochemical properties and spectroscopic data. Results Eleven compounds were isolated from 70% ethanol extract of dried roots of P. notoginseng, including five terpenoids, three pyranones, one furanone, one phenolic glycoside and one other. Their structures were identified as (S)-2-ethyl-6-hydroxy-7-methoxyphthalide-6-α-L-rhamnosyl-(1→6)-β-D-glucopyranoside (1), △⁸⁽⁹⁾-(Z)-(R)-6-(1-hydroxyhextyl)-4-methoxy-2(5H)-pyranone (2), 6-(1-hydroxypentyl)- 4-methoxy-2(5H)-pyranone (3), 6-(1-hydroxyhextyl)-5-hydroxy-3-methoxy-2(5H)-pyranone (4), aromadendrane-4β,10α-diol (5), isodauc-6-ene-10β,14-diol (6), 1β,6α-dihydroxyeudesma-4(15)-ene (7), nitidumine D (8), nitidumine C (9), 5-(1-hydroxyheptyl)-3-methoxy-2(5H)-furanone (10), 3E-5-methoxy-6-hydroxy-6-methyl-3-hepten-2-one (11), respectively. Conclusion Compounds 1 and 2 are new compounds and named as panaphthaloside and panapyranone, respectively. Compounds 6, 8, 9 and 11 were isolated from P. notoginseng for the first time.

云南省产业创新人才项目；中国科学院青年创新促进会项目（2021390）；Bualuang ASEAN Chair Professor Research Grand，泰国