原儿茶醛是一种存在于常用中药及一些草本植物中的酚酸类化合物，已被证明具有多种药理活性，如抗动脉粥样硬化、抗血栓形成、保护心肌细胞等。近年来的研究结果显示原儿茶醛对多种神经系统疾病具有改善作用，表明其在神经病变方面具有潜在的开发应用前景。结合国内外最新报道，综述了近25年原儿茶醛的神经保护作用及其机制的研究进展，为原儿茶醛用于神经系统疾病的进一步研究提供依据和思路。

Protocatechuic aldehyde is a phenolic acid compound existing in common traditional Chinese medicine and some herbs. It has been proved to have a variety of pharmacological activities, such as anti-atherosclerosis, anti-thrombosis, and protection of myocardial cells. Recent research results showed that protocatechuic aldehyde could improve a variety of nervous system diseases, indicating that it has potential development and application prospects in neuropathy. Based on the latest reports at home and abroad, this paper reviews the research progress on the neuroprotective effect and mechanism of protocatechuic aldehyde in the past 25 years, providing the basis and ideas for further research on the application of protocatechuic aldehyde in nervous system diseases.

国家自然科学基金资助项目（81801522）；河北省自然科学基金中医药联合基金重点项目（H2023209038）；河北省高等学校科学技术研究项目（ZD2022141）