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2025年6月13日 7:16 星期五
首页 > 过刊浏览>2024年第55卷第7期 >2024,55(7):2442-2451. DOI:10.7501/j.issn.0253-2670.2024.07.030
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从神经炎症角度论丹栀逍遥散抗抑郁作用机制的研究进展

Research progress on anti-depression effect of Danzhi Xiaoyao Powder from perspective of neuroinflammation

发布日期：2024-04-03
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    [关键词]
    [摘要]
    在全球范围内，抑郁症是导致自杀的主要原因之一，造成巨大的经济损失和社会负担。其病因复杂，临床症状多样，确切的发病机制暂无定论。中医理论认为“郁证”的“气郁化火”证型与炎症关系密切。近年来，大量研究证实神经炎症调控在抑郁症发病过程中起到关键作用，提示从神经炎症的角度研发新型抗抑郁药物具有广阔前景。丹栀逍遥散可通过减轻神经炎症治疗抑郁症，且具有显著疗效，相比临床常用抗抑郁药物显示出诸多优势。目前关于丹栀逍遥散基于炎症通路发挥抗抑郁功效的机制探讨较少，因此基于抑郁症的神经炎症发病机制，结合中医“郁证”理论，从丹栀逍遥散及方中药对和核心抗炎活性成分的抗抑郁作用机制进行综述，为丹栀逍遥散及其类方抗抑郁功效提供科学依据，也为抑郁症的机制研究和新型抗抑郁药物研发提供借鉴。
    [Key word]
    [Abstract]
    Globally, depression is one of the leading causes of rising suicide rates, resulting in huge economic losses and social burdens. The etiology of depression is complex and the clinical symptoms are varied, and the exact pathogenesis is still uncertain. Traditional Chinese medicine (TCM) classifies depression as “Yu syndrome” and the TCM theory hold that the syndrome type of “qi depression transforming into fire” is closely related to inflammation. In recent years, more and more studies have confirmed that the regulation of neuroinflammation plays a key role in the pathogenesis of depression, suggesting that the development of new antidepressant drugs from the perspective of neuroinflammation has broad prospects. With the deepening of clinical and experimental research, the classical prescription Danzhi Xiaoyao Powder (丹栀逍遥散) has remarkable efficacy in the treatment of depression by reducing neuroinflammation, and shows many advantages compared with common clinical antidepressants. At present, there are few discussions on the mechanism of antidepressant effect of Danzhi Xiaoyao Powder based on inflammation pathway. Therefore, based on the pathogenesis of neuroinflammation of depression, combined with the TCM theory of “Yu syndrome”, the anti-depressant mechanism of Danzhi Xiaoyao Powder, medicine pairs and the core anti-inflammatory active ingredients were reviewed in this study, aiming to provide scientific basis for the anti-depressant effect of Danzhi Xiaoyao Powder and its associated prescriptions, and also provide references for the mechanism research of depression to develop new antidepressant drugs.
    [基金项目]
    国家中医药管理局科技司“张仲景传承与创新专项”（GZY-KJS-2022-048-1）；国家自然科学基金资助项目（82274496）；河南省科技攻关项目（232102310419）
    [1] 吴振宁, 王琦, 秦雪梅, 等. 肠道菌群及其代谢产物在中药治疗抑郁症中的研究进展[J]. 中草药, 2023, 54(14):4713-4721.
    [2] Koo J W, Labonté B, Engmann O, et al. Essential role of mesolimbic brain-derived neurotrophic factor in chronic social stress-induced depressive behaviors[J]. Biol Psychiatry, 2016, 80(6):469-478.
    [3] Andersen B L, Goyal N G, Westbrook T D, et al. Trajectories of stress, depressive symptoms, and immunity in cancer survivors:Diagnosis to 5 years[J]. Clin Cancer Res, 2017, 23(1):52-61.
    [4] 王力文, 黄德华, 田俊生, 等. 基于外周血单个核细胞转录组学的柴归颗粒抗抑郁作用机制研究[J]. 中草药, 2022, 53(7):2031-2043.
    [5] Obasi E M, Chen T A, Cavanagh L, et al. Depression, perceived social control, and hypothalamic-pituitary-adrenal axis function in African-American adults[J]. Health Psychol, 2020, 39(2):107-115.
    [6] Menard C, Pfau M L, Hodes G E, et al. Social stress induces neurovascular pathology promoting depression[J]. Nat Neurosci, 2017, 20(12):1752-1760.
    [7] 马丹凤, 陈蕾, 张传香, 等. 木犀草素调控JAK1/STAT3通路对抑郁症大鼠海马小胶质细胞极化的影响[J]. 药物评价研究, 2021, 44(12):2587-2594.
    [8] Lamers F, Milaneschi Y, de Jonge P, et al. Metabolic and inflammatory markers:Associations with individual depressive symptoms[J]. Psychol Med, 2018, 48(7):1102-1110.
    [9] Lu Y X, Ho C S, Liu X, et al. Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression[J]. PLoS One, 2017, 12(10):e0186700.
    [10] 王春芳, 田文国, 陈金鹏, 等. 中药抗抑郁作用及其机制研究进展[J]. 中草药, 2022, 53(9):2890-2901.
    [11] Dantzer R, O'Connor J C, Freund G G, et al. From inflammation to sickness and depression:When the immune system subjugates the brain[J]. Nat Rev Neurosci, 2008, 9(1):46-56.
    [12] Levine J, Barak Y, Chengappa K N, et al. Cerebrospinal cytokine levels in patients with acute depression[J]. Neuropsychobiology, 1999, 40(4):171-176.
    [13] 王天鸣. 疏肝泻火方治疗抑郁状态(气郁化火证)的临床研究[D]. 长春:长春中医药大学, 2020.
    [14] 刘磊, 李冰冰. "慢性应激-免疫微环境重塑"视角下的乳腺癌肝郁证治解读[J]. 疑难病杂志, 2023, 22(9):999-1003.
    [15] 黄杨. 基于文献及临床证据探究抑郁症中医辨证分型及其与客观指标的相关性研究[D]. 天津:天津中医药大学, 2021.
    [16] 武小玲, 王森岩, 赵思俊, 等. 选择性5-羟色胺再摄取抑制剂联合用药治疗难治性抑郁症研究进展[J]. 中国药理学与毒理学杂志, 2022, 36(10):776-783.
    [17] Yun S, Reynolds R P, Petrof I, et al. Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive[J]. Nat Med, 2018, 24(5):658-666.
    [18] 司天梅, 王振, 李凌江. 抗抑郁药品临床综合评价专家共识[J]. 中国药房, 2023, 34(13):1547-1554.
    [19] 张明远, 许二平, 尚立芝, 等. 酸枣仁汤及其组分治疗抑郁症的研究进展[J]. 中华中医药学刊, 2022, 40(6):48-54.
    [20] 陆登成. 肝郁化火型焦虑行为大鼠小胶质细胞活化及丹栀逍遥散的干预作用[D]. 昆明:云南中医药大学, 2020.
    [21] 谭思琦, 谢荣芳, 田鑫, 等. 丹栀逍遥散加减联合糖皮质激素治疗肝郁气滞型视神经炎疗效观察[J]. 江西中医药, 2022, 53(4):36-38.
    [22] 李肖, 宫文霞, 周玉枝, 等. 逍遥散中抗抑郁有效成分及其作用机制研究进展[J]. 中草药, 2015, 46(20):3109-3116.
    [23] 张宝宝, 姚菁, 金海燕, 等. 柴胡-白芍醇提液抗抑郁和保肝作用实验研究[J]. 甘肃中医学院学报, 2016, 33(6):10-15.
    [24] 刘佳莉, 苑玉和, 陈乃宏. 抑郁症的治疗研究进展[J]. 中国药理学通报, 2011, 27(9):1193-1196.
    [25] Smith R S. The macrophage theory of depression[J]. Med Hypotheses, 1991, 35(4):298-306.
    [26] Dean B, Tawadros N, Scarr E, et al. Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder[J]. J Affect Disorders, 2010, 120(1-3):245-248.
    [27] Yu Y W Y, Chen T J, Hong C J, et al. Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response[J]. Neuropsychopharmacology, 2003, 28(6):1182-1185.
    [28] Jun T Y, Pae C U, Hoon-Han, et al. Possible association between-G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population[J]. Psychiatr Genet, 2003, 13(3):179-181.
    [29] Beydoun M A, Obhi H K, Weiss J, et al. Systemic inflammation is associated with depressive symptoms differentially by sex and race:A longitudinal study of urban adults[J]. Mol Psychiatry, 2020, 25(6):1286-1300.
    [30] Pape K, Tamouza R, Leboyer M, et al. Immunoneuropsychiatry-novel perspectives on brain disorders[J]. Nat Rev Neurol, 2019, 15(6):317-328.
    [31] 张楠, 许二平, 陈玉龙. NLRP3炎症小体与抑郁症的关系及中医药的干预作用[J]. 中国实验方剂学杂志, 2023, 29(3):186-193.
    [32] Nettis M A, Pariante C M. Is there neuroinflammation in depression? Understanding the link between the brain and the peripheral immune system in depression[J]. Int Rev Neurobiol, 2020, 152:23-40.
    [33] Setiawan E, Wilson A A, Mizrahi R, et al. Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes[J]. JAMA Psychiatry, 2015, 72(3):268-275.
    [34] Hannestad J, DellaGioia N, Gallezot J D, et al. The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression:A[¹¹C]PBR28 PET study[J]. Brain Behav Immun, 2013, 33:131-138.
    [35] Raison C L, Dantzer R, Kelley K W, et al. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha:Relationship to CNS immune responses and depression[J]. Mol Psychiatry, 2010, 15(4):393-403.
    [36] Troubat R, Barone P, Leman S, et al. Neuroinflammation and depression:A review[J]. Eur J Neurosci, 2021, 53(1):151-171.
    [37] Walker A K, Kavelaars A, Heijnen C J, et al. Neuroinflammation and comorbidity of pain and depression[J]. Pharmacol Rev, 2014, 66(1):80-101.
    [38] Atanasova D, Lazarov N, Stoyanov D S, et al. Reduced neuroinflammation and enhanced neurogenesis following chronic agomelatine treatment in rats undergoing chronic constant light[J]. Neuropharmacology, 2021, 197:108706.
    [39] Quan N, Whiteside M, Herkenham M. Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide[J]. Neuroscience, 1998, 83(1):281-293.
    [40] 曾九僧, 纪雅菲, 方洋, 等. NLRP3炎症小体在抑郁症中的作用及中药干预研究进展[J]. 中草药, 2021, 52(11):3418-3428.
    [41] Nusslock R, Brody G H, Armstrong C C, et al. Higher peripheral inflammatory signaling associated with lower resting-state functional brain connectivity in emotion regulation and central executive networks[J]. Biol Psychiatry, 2019, 86(2):153-162.
    [42] Schain M, Kreisl W C. Neuroinflammation in neurodegenerative disorders-A review[J]. Curr Neurol Neurosci Rep, 2017, 17(3):25.
    [43] 刘若楠, 古力巴克然木·阿布拉, 沈小琴, 等. 雷公藤甲素通过上调miR-137调控小胶质细胞极化改善大鼠抑郁样行为[J]. 现代药物与临床, 2023, 38(5):1021-1027.
    [44] Yirmiya R, Rimmerman N, Reshef R. Depression as a microglial disease[J]. Trends Neurosci, 2015, 38(10):637-658.
    [45] Ślusarczyk J, Trojan E, Głombik K, et al. Targeting the NLRP3 inflammasome-related pathways via tianeptine treatment-suppressed microglia polarization to the M1 phenotype in lipopolysaccharide-stimulated cultures[J]. Int J Mol Sci, 2018, 19(7):1965.
    [46] Jia X N, Gao Z H, Hu H L. Microglia in depression:Current perspectives[J]. Sci China Life Sci, 2021, 64(6):911-925.
    [47] Xu N, Tang X H, Pan W, et al. Spared nerve injury increases the expression of microglia M1 markers in the prefrontal cortex of rats and provokes depression-like behaviors[J]. Front Neurosci, 2017, 11:209.
    [48] Zhang J Q, Xie X F, Tang M M, et al. Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice[J]. Brain Behav Immun, 2017, 66:111-124.
    [49] Hoogland I C, Houbolt C, van Westerloo D J, et al. Systemic inflammation and microglial activation:Systematic review of animal experiments[J]. J Neuroinflammation, 2015, 12:114.
    [50] 刘启华, 凌江红. 肝气郁结与肝郁化火探讨[A]//第二届国际抑郁共病暨第十二届中国中西医结合基础理论学术研讨会论文集[C]. 南京:中国中西医结合学会, 2016:246-247.
    [51] 葛娜, 巩江, 倪士峰, 等. "上火""发炎"与自由基的关系[J]. 辽宁中医药大学学报, 2011, 13(2):87-89.
    [52] 黎杏群, 张海男, 金益强, 等. 肝火上炎证的病理生理学基础研究[J]. 中医杂志, 2002, 43(1):54-56.
    [53] 何汝帮, 杨安平. "上火"证发病机理的研究综述[J]. 亚太传统医药, 2008, 4(12):144-145.
    [54] 连卓, 田可为. 舒肝和络饮治疗肝火郁结型抑郁症40例[J]. 河南中医, 2008, 28(12):54-55.
    [55] 赵昕. 原发性头痛肝火上扰证和焦虑、抑郁的相关性分析[D]. 北京:北京中医药大学, 2019.
    [56] 杞红梅. 丹栀逍遥散治疗郁病(血管性抑郁)肝郁气滞证的临床研究[D]. 昆明:云南中医药大学, 2019.
    [57] 张笑. 丹栀逍遥散加减配合针刺疗法治疗中风后抑郁(气郁化火型)的临床研究[D]. 长春:长春中医药大学, 2017.
    [58] 陈涛, 陈丰. 丹栀逍遥散治疗气郁化火型抑郁症40例临床观察[J]. 中国继续医学教育, 2018, 10(33):149-151.
    [59] 何梦璇. 丹栀逍遥散治疗轻中度抑郁症的疗效观察及机制研究[J]. 名医, 2019(2):260.
    [60] 江利敏, 刘向哲. 丹栀逍遥散加减治疗卒中后抑郁的疗效及作用机制[J]. 中国实验方剂学杂志, 2019, 25(3):108-113.
    [61] 李玉娟, 罗和春, 钱瑞琴, 等. 丹栀逍遥散对抑郁症患者神经免疫内分泌系统的影响[J]. 中国中西医结合杂志, 2007, 27(3):197-200.
    [62] 刘俊德. 丹栀逍遥散治疗混合性焦虑抑郁障碍的临床研究[J]. 河南中医, 2004, 24(8):26-27.
    [63] 徐明月, 邹勇, 宫鑫. 丹栀逍遥丸干预原发性老年高血压患者合并抑郁情绪的临床机理研究[J]. 中医临床研究, 2018, 10(11):8-10.
    [64] 张岩. 丹栀逍遥丸干预原发性老年高血压患者合并抑郁情绪的临床机理研究[J]. 中国处方药, 2019, 17(4):103-104
    [65] 罗和春, 钱瑞琴, 赵学英, 等. 丹栀逍遥散治疗抑郁症的临床疗效观察[J]. 中国中西医结合杂志, 2006, 26(3):212-214.
    [66] 徐道祥, 史惠敏, 林小东. 盐酸帕罗西汀联合丹栀逍遥丸治疗抑郁症伴焦虑的临床对照研究[J]. 中国临床药理学与治疗学, 2017, 22(3):321-325.
    [67] 李敏昌, 陈英歌. 丹栀逍遥散联合艾司西酞普兰治犗?审ㄧヴ?崴?嫁梄斗湈柂?塛???栠敷湗朻?夬?′?栲攲測?夳???椴?攺琳?愸水??椱????敢牲甾汛椶挸?愠掸榌摳?椠涋瀟牰漬瘠旗猎?搬攠灉爮攠猹猀植癥散?氈椟歿敀?抗攭棎愎皑槁濇爲‰椰溋?灊牝攮渠憳瑗愭氻氬礠?猰琱爷攬猠猳攷搨?漩昺昷猹瀭爸椱渮朼?牲愾瑛猶?癝椠懫?憰渮琠椹?植湥晣汔愈洕浗慿瑀澻犗禑?懇捛瑊楝瘮椠瑉礎?愻測搠′?倱??愠砳椲猨嬱?崩?′?椹??渲琳????潢汲￣卛挷椰??榐???代　ㄍ????バ????????抑郁症患者的临床疗效及药物作用机制[J]. 中国药物经济学, 2021, 16(2):91-94.
    [71] 王开欣, 孙雪平, 罗涛, 等. 丹栀逍遥散联合五行音乐疗法治疗轻度卒中后抑郁患者临床研究[J/OL]. 辽宁中医杂志,[2023-12-14]. http://kns.cnki.net/kcms/detail/21.1128.R.20231214.1307.003.html.
    [72] 贺晶, 高晓霞, 田俊生, 等. UPLC-MS分析柴胡、白芍水煎液的化学成分及其对逍遥散的贡献[J]. 山西医科大学学报, 2018, 49(4):375-382.
    [73] 林薇, 赵荷, 郝怡雯, 等. 基于Copula函数研究柴胡-白芍药对在治疗"肝郁血虚"方剂中的剂量相关性[J]. 中草药, 2021, 52(13):4007-4013.
    [74] 雒明池, 梁如, 高树明, 等. 基于cAMP-CREB-BDNF通路探讨柴胡-白芍药对抗抑郁作用机制[J]. 中草药, 2018, 49(17):4093-4098.
    [75] 张冠英, 张洪财, 王文姌. 基于网络药理学探讨柴胡-白芍治疗MDD作用机制[J]. 哈尔滨商业大学学报:自然科学版, 2022, 38(5):515-521.
    [76] 张心一, 江汉美, 成立, 等. HS-SPME-GC-MS分析柴胡、白芍配伍前后挥发性组分变化规律[J]. 天然产物研究与发, 2023, 35(11):1907-1914.
    [77] 李钰杰, 马进. 基于网络药理学探讨牡丹皮-栀子治疗抑郁症的作用机制[J]. 辽宁中医药大学学报, 2024, 26(2):198-205.
    [78] 张雪竹, 白旭光, 戴旖旎, 等. 基于网络药理学的"白术-茯苓"药对作用机制分析[J]. 临床医学研究与实践, 2019, 4(15):1-3.
    [79] 杨永红. 丹栀逍遥散6种有效成分的HPLC测定[J]. 中国实验方剂学杂志, 2014, 20(16):97-99.
    [80] Qin F, Huang J, Qiu X J, et al. Quality control of modified Xiaoyao San through the determination of 22 active components by ultra-performance liquid chromatography[J]. J AOAC Int, 2011, 94(6):1778-1784.
    [81] Zhu Y L, Li S L, Jin J L, et al. Simultaneous determination of six components of Danzhi Xiaoyao Pill in beagle plasma by HPLC-MS/MS and a study of pharmacokinetic of paeoniflorin and geniposide after single-dose administration[J]. J Pharm Biomed Anal, 2020, 186:113269.
    [82] Chen T, Liu S N, Zheng M L, et al. The effect of geniposide on chronic unpredictable mild stress-induced depressive mice through BTK/TLR4/NF-κB and BDNF/TrkB signaling pathways[J]. Phytother Res, 2021, 35(2):932-945.
    [83] Zou T Y, Sugimoto K, Zhang J L, et al. Geniposide alleviates oxidative stress of mice with depression-like behaviors by upregulating Six3os1[J]. Front Cell Dev Biol, 2020, 8:553728.
    [84] Araki R, Hiraki Y, Yabe T. Genipin attenuates lipopolysaccharide-induced persistent changes of emotional behaviors and neural activation in the hypothalamic paraventricular nucleus and the central amygdala nucleus[J]. Eur J Pharmacol, 2014, 741:1-7.
    [85] Zheng M L, Li K, Chen T, et al. Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice[J]. Brain Res Bull, 2021, 170:65-73.
    [86] Ma S L, Zhang C, Zhang Z Y, et al. Geniposide protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via up-regulation of miR-145-5p[J]. Artif Cells Nanomed Biotechnol, 2019, 47(1):2875-2881.
    [87] Cheng J, Chen M, Wan H Q, et al. Paeoniflorin exerts antidepressant-like effects through enhancing neuronal FGF-2 by microglial inactivation[J]. J Ethnopharmacol, 2021, 274:114046.
    [88] Tian D D, Wang M, Liu A, et al. Antidepressant effect of paeoniflorin is through inhibiting pyroptosis CASP-11/GSDMD pathway[J]. Mol Neurobiol, 2021, 58(2):761-776.
    [89] Tao W W, Wang H Q, Su Q, et al. Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice[J]. Psychiatry Res, 2016, 238:116-121.
    [90] Shin J S, Im H T, Lee K T. Saikosaponin B2 suppresses inflammatory responses through IKK/IκBα/NF-κB signaling inactivation in LPS-induced RAW264.7 macrophages[J]. Inflammation, 2019, 42(1):342-353.
    [91] Liu C, Yuan D, Zhang C, et al. Liquiritin alleviates depression-like behavior in CUMS mice by inhibiting oxidative stress and NLRP3 inflammasome in hippocampus[J]. Evid Based Complement Alternat Med, 2022, 2022:7558825.
    [92] Chen M, Zhang Q P, Zhu J X, et al. Involvement of FGF-2 modulation in the antidepressant-like effects of liquiritin in mice[J]. Eur J Pharmacol, 2020, 881:173297.
    [93] Zhou Y, Huang S H, Wu F L, et al. Atractylenolide III reduces depressive- and anxiogenic-like behaviors in rat depression models[J]. Neurosci Lett, 2021, 759:136050.
    [94] Novianti E, Katsuura G, Kawamura N, et al. Atractylenolide-III suppresses lipopolysaccharide-induced inflammation via downregulation of toll-like receptor 4 in mouse microglia[J]. Heliyon, 2021, 7(10):e08269.
    [95] Zhou K C, Chen J, Wu J Y, et al. Atractylenolide III ameliorates cerebral ischemic injury and neuroinflammation associated with inhibiting JAK2/STAT3/Drp1-dependent mitochondrial fission in microglia[J]. Phytomedicine, 2019, 59:152922.
    [96] Gong W X, Zhou Y Z, Qin X M, et al. Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κB inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells[J]. Chin J Nat Med, 2019, 17(4):264-274.
    [97] 吴川, 孔安琪, 谢汝欣, 等. 柚皮苷改善脂多糖诱导的小鼠抑郁样行为的作用研究[J]. 陆军军医大学学报, 2022, 44(23):2368-2376.
    [98] Oladapo O M, Ben-Azu B, Ajayi A M, et al. Naringin confers protection against psychosocial defeat stress-induced neurobehavioral deficits in mice:Involvement of glutamic acid decarboxylase isoform-67, oxido-nitrergic stress, and neuroinflammatory mechanisms[J]. J Mol Neurosci, 2021, 71(3):431-445.
    [99] Kosari-Nasab M, Shokouhi G, Ghorbanihaghjo A, et al. Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury[J]. Life Sci, 2018, 213:198-205.
    [100] Fu H L, Liu L, Tong Y, et al. The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice[J]. Eur J Pharmacol, 2019, 853:236-246.
    [101] Salama A, Gouida M S O, Yassen N N, et al. Immunoregulatory role of hesperidin against ovalbumin (OVA)-induced bronchial asthma and depression in rats[J]. Naunyn Schmiedebergs Arch Pharmacol, 2023, doi:10.1007/s00210-023-02833-7.
    [102] Liu Y M, Shen J D, Xu L P, et al. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress[J]. Int Immunopharmacol, 2017, 45:128-134.
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