由于生长因子类生物制剂药物在治疗伤口愈合中的局限性，从传统中药中挖掘缓解炎症反应、促血管生成、重塑上皮组织、加速伤口愈合的中药及其活性成分，对治疗慢性伤口有积极意义。除传统的活血止血类药物如丹参Salviae Miltiorrhizae Radix et Rhizoma、三七Notoginseng Radix et Rhizoma、姜黄Curcumae Longae Rhizoma、乳香Olibanum等及其活性成分外，清热药如积雪草Centellae Herba、黄连Coptidis Rhizoma，补益药中黄芪Astragali Radix、淫羊藿Epimedii Folium等及其活性成分，复方托里消毒散、生肌化瘀汤等在伤口愈合各阶段都具有积极的调控作用。通过对活血止血类、清热类、补益类药物及其活性成分和复方治疗伤口愈合作用机制进行综述，为了解中药药效物质在治疗慢性伤口的相关研究提供参考和依据。

Because of the limitations of growth factor-containing biologic drugs in the treatment of wound healing, the exploration of traditional Chinese medicines and their active ingredients which can alleviate inflammatory reactions, promote angiogenesis, remodel epithelial tissues and accelerate wound healing has positive significance in the treatment of the chronic wounds. In addition to traditional blood-activating and hemostatic drugs, such as Danshen (Salviae Miltiorrhizae Radix et Rhizoma), Sanqi (Notoginseng Radix et Rhizoma), Jianghuang (Curcumae Longae Rhizoma), Ruxiang (Olibanum) and their active ingredients, we also found that heat-cleansing drugs such as Jixuecao (Centellae Herba) and Huanglian (Coptidis Rhizoma), and tonic drugs such as Huangqi (Astragali Radix), Yinyanghuo (Epimedii Folium), as well as their active ingredients, and the compound formulas of tuolixiaodu (复方托里消毒散), Shengjihuayu (生肌化瘀汤), all of which play an active role in the regulation of the various phases of the wound healing. The research progress of the mechanism of action of blood-activating and hemostatic drugs, heat-clearing and tonic drugs, their active ingredients and compound formulas in the treatment of wound healing is mainly reviewed, providing references and basis for understanding the related researches on the pharmacodynamic substances of traditional Chinese medicines in the treatment of chronic wounds.

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国家自然科学基金资助项目（81973567）