中医学强调整体观和辨证论治，在临床应用中多以复方的形式给药。中药复方成分复杂，各成分间相互作用，呈现多成分、多靶点、多途径的特点。在中药“整体调控”的认知模式下，中药复方制剂的作用机制尚不明确。代谢组学通过研究生物体体内的代谢变化来表征药物进入机体后的作用机制，其分析生物体代谢情况动态变化的整体性、系统性与中医“整体观”特点相吻合，与中医药的多靶点、多途径的特色相契合，近年来在中药研究中应用较广泛。通过对近年来代谢组学的研究思路及其在中药复方制剂研究中的应用进行综述，分析目前面临的挑战，为进一步完善代谢组学研究方法并阐明中药复方制剂作用机制提供新思路。

Traditional Chinese medicine (TCM) emphasizes the holistic view and syndrome differentiation and treatment, and is mostly administered in the form of compound in clinical application. The components of TCM compound are complex and interact with each other, showing the characteristics of multi-component, multi-target and multi-pathway. Under the cognitive mode of “holistic regulation” of TCM, the mechanism of action of TCM compound preparations is still unclear. Metabolomics can characterize the mechanism of action of drugs after entering the body by studying the metabolic changes in the body. Its holistic and systematic analysis of the dynamic changes of organism metabolism is consistent with the characteristics of the “holistic view” of TCM, and is consistent with the characteristics of multi-target and multi-channel of TCM. In recent years, it has been widely used in the study of TCM. This paper reviews the research ideas of metabolomics in recent years and its application in the research of TCM compound preparations, analyzes the current challenges, and provides new ideas for further improving metabolomics research methods and elucidating the mechanism of TCM compound preparations.

四川省科技成果转移转化示范项目（2023ZHCG0071）