目的 建立多组分定量联合化学计量学及熵权TOPSIS分析对不同产地所得青钱柳Cyclocarya paliurus质量进行评价的方法，为青钱柳药材的品质评价和质量控制提供参考。方法 取不同产地所得18批青钱柳为检测样品，以熊果酸为内参物，采用一测多评（quantitative analysis of multi-components by single-marker，QAMS）法同时测定青钱柳中14个成分的含量，运用化学计量学和熵权TOPSIS分析法对不同产地青钱柳进行比较分析和综合评价。结果 含量测定方法学考察结果符合中国药典规定要求。以熊果酸为内参物的相对校正因子稳定性、耐用性良好（RSD均小于2.0%），外标法实测值与QAMS法计算结果没有显著差异。化学计量学方法显示18批青钱柳可聚为3类，呈现一定的区域差异；槲皮素-3-O-葡萄糖醛酸苷、金丝桃苷、熊果酸、阿福豆苷和异槲皮苷是影响青钱柳产品质量的主要成分；EW-TOPSIS法分析结果显示贵州和四川地区所得青钱柳质量最优，其次为湖南、江西和安徽。结论 所建方法快速灵敏、准确可靠，可用于青钱柳内在质量的综合质量评价。

Objective To establish a method for evaluating the quality of Cyclocarya paliurus obtained from different regions using multi-component quantification combined with chemometrics and entropy weight TOPSIS (EW-TOPSIS) analysis, to provide reference for quality evaluation and quality control of C. paliurus medicinal materials. Methods A total of 18 batches of C. paliurus from different habitats were used as test samples, ursolic acid was used as internal reference substance, the contents of 14 components in C. paliurus were determined by QAMS, the comparative analysis and comprehensive evaluation of C. paliurus from different habitats were carried out by chemometrics and EW-TOPSIS. Results The results of content determination methodology met the relevant requirements of Chinese pharmacopoeia. The relative correction factor of ursolic acid as the internal reference material was stable and durable (RSD was less than 2.0%). There was no significant difference between the measured value by external standard method and the calculated result by QAMS method. Chemometrics method showed that 18 batches of C. paliurus could be clustered into three categories, showing a certain regional differences. Quercetin 3-O-β-D-glucuronide, hyperoside, ursolic acid, afzelin and isoquercitrin were the main components affecting the quality of C. paliurus. The results of EW-TOPSIS analysis showed that the quality of C. paliurus in Guizhou and Sichuan were the best, followed by Hunan, Jiangxi and Anhui. Conclusion The established method is fast, sensitive and reliable, and can be suitable for comprehensive evaluation of the internal quality of C. paliurus.

河南省医学教育研究项目（Wjlx2021328）；河南省医学教育研究项目（Wjlx2021328）