偏头痛是一种以发作性偏侧头痛为主要特征的神经系统疾病，其发病机制复杂，病情迁延难愈，具有高发病率、高致残率等特点，给患者和社会带来巨大负担，目前西医以预防性治疗和对症治疗为主，且存在诸多不良反应，而中医药在偏头痛的治疗上具有明显优势，川芎Chuanxiong Rhizoma作为治疗偏头痛的常用药物，临床上疗效显著。其治疗偏头痛的机制可能与调节血管收缩因子、调控五羟色胺及多巴胺等神经递质、调节内源性物质代谢、调控过氧化物酶体增殖物激活受体γ、细胞黏附分子、核因子-κB和丝裂原活化蛋白激酶信号通路等有关，通过对川芎活性成分、药对、中药复方等抗偏头痛的相关基础研究与临床研究进展进行归纳总结，为川芎在治疗偏头痛的临床应用方面提供参考。

Migraine is a neurological disease mainly characterized by episodic lateral headache, its pathogenesis is complex, with long courses and low cure rate, with high morbidity and high disability rate, which brings a huge burden to the patients and the society. At present, western medicine is based on the preventive treatment and symptomatic treatment, with lots of adverse reactions; While Chinese medicine has obvious advantages in the treatment of migraine. Chuanxiong (Chuanxiong Rhizoma) as a commonly used drug for the treatment of migraine has remarkable clinical efficacy. Its mechanism of migraine treatment may be related to the regulation of vasoconstrictor factors, the regulation of neurotransmitters such as serotonin and dopamine, the regulation of endogenous substance metabolism, the regulation of peroxisome proliferator-activated receptor γ, cell adhesion molecules, nuclear factor-κB and mitogen-activated protein kinase signaling pathway, etc. By summarizing the progress of the basic research and clinical studies on the active ingredients, pairs of medicines, and Chinese herbal medicine prescriptions of Chuanxiong Rhizoma, aiming to provide a reference for the clinical application of Chuanxiong Rhizoma in the treatment of migraine.

陕西省重点研发计划项目（2018SF-297）；中国中医科学院中医药循证能力建设项目（2019XZZX-NB010）；陕西省教育厅重点科学研究计划项目（21JS006）