目的 以祖师麻Daphnes Giraldii Cortex不同体积分数乙醇渗漉流浸膏为药物模型，研究其对后交联凝胶基质黏弹性及释药性的影响。方法 结合黏附力测试、流变学指标、体外释放度试验及相关性分析，考察不同祖师麻提取物出膏率、软化点及pH值对后交联凝胶基质成型过程中关键流变学参数及贴膏释药性的影响。结果 当乙醇体积分数在75%～95%时，祖师麻提取物出膏率及pH值随乙醇体积分数的升高而显著降低，软化点则相反。出膏率主要通过影响基质的复合模量（G^*）及屈服应力（τ）值来影响贴膏内聚力及抗剪切能力，软化点和pH值主要通过影响基质G^*、τ、弹性模量（G′）、G值来影响贴膏的结构稳定性、抗剪切性、初黏力及剥离强度。体外释药结果显示，祖师麻甲素10 h内的累积释药率随提取物醇提体积分数的升高而增大，但提取物3个理化性质对释药率的影响并不显著。结论 不同祖师麻提取物对后交联基质的性能影响总体差异不大，通过检测基质相关的流变学指标可以有目的地对基质配方进行相应调整，从而进一步提高贴膏的成型质量和后交联基质的普遍适用性。

Objective Using ethanol percolation fluid extract with different volume fractions of Zushima (Daphnes Giraldii Cortex, DGC) as the drug model to study its effects on viscoelasticity and drug release of post-crosslinked gel matrix. Methods Combined with adhesion testing, rheological techniques, in vitro release investigation and correlation analysis, the effects of different DGC extracts in terms of the paste-forming rate, softening point and pH on the key rheological parameters and paster release properties during the molding process of post- crosslinking gel matrix were investigated. Results When the ethanol volume fraction was in the range of 75%−95%, the paste-forming rate and pH of DGC extracts decreased significantly with the increase of ethanol volume fraction, while the softening point was the opposite. The paste-forming rate mainly influenced the cohesion and shear resistance of the paster by affecting the matrix complex modulus (G^*) and yield stress (τ) value. The softening point and pH value mainly influenced the structural stability, shear resistance, initial adhesion and peel strength of the paster by affecting the matrix G^*,τ, G′, G value. The in vitro release results showed that the cumulative release rate of daphnetin within 10 h increased with the increase of the alcoholic extraction volume fraction of the extract, but there was no significant association between the release rate and the three physicochemical properties of the extract. Conclusion The overall difference in the performance of post-crosslinking matrix affected by different extracts of DGC are not significant, and the matrix formulation could be purposefully adjusted accordingly by testing the rheological indexes related to the matrix, thus further improving the molding quality of the paster and the general applicability of the post-crosslinking matrix.

甘肃省优秀博士生项目（22JR5RA578）