地龙Pheretima是临床常用动物药，广泛应用于小儿惊风、高热抽搐等儿科疾病的治疗及溶栓、卒中后遗症等心脑血管疾病的防治。但地龙药材、饮片及相关中成药具有显著的腥臭气，热水冲服时尤为强烈，导致患者服药顺应性差，尤其不利于儿童自主服药。究其根本，是地龙腥臭气物质的基础研究不深、产生的主要途径不明、矫臭技术有待提高。为此，归纳了地龙腥臭气的物质基础及其3种腥臭气特征分型，分析了生长代谢、生长环境、产地加工等多因素对地龙腥臭气物质形成的影响规律，总结了传统炮制技术、气味吸附技术、包合技术、包衣技术等矫臭方法对地龙腥臭气的掩蔽效果，为解决地龙的腥臭气难题、推动地龙相关产品的高质量创新发展提供参考。

Dilong (Pheretima) is a commonly used animal medicine in clinic, widely used in the treatment of pediatric diseases such as convulsions and high fever, as well as the prevention and treatment of cardiovascular and cerebrovascular diseases such as thrombolysis and stroke sequelae. However, the Pheretima medicinal materials, decoction pieces and related Chinese patent medicines have significant stenchy odor, which is particularly strong when taken in hot water, resulting in poor compliance of patients, especially not conducive to children's self-medication. The fundamental reason is that the basic research on the substances with stenchy odor of the Pheretima is relatively shallow, the main pathways of their generation are unclear, and the technology for masking and correcting the stenchy odor needs to be improved. Therefore, this paper summarizes the material basis and three types of stenchy odor characteristics in the Pheretima, analyzes the influence of multiple factors such as growth metabolism, growth environment, processing of production place on the formation of the stenchy odor substances in the Pheretima, and summarizes the masking effect of traditional processing technology, odor adsorption technology, inclusion technology, coating technology and other odor correction methods on the stench of the Pheretima, aiming at solving the problem of the stench of the Pheretima and promoting the high-quality innovation and development of the related products.

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国家自然科学基金资助项目（82173991）；成都中医药大学杏林学者提升计划青年科技创新团队项目（QNTD2022002）