中药材在种植、采收、贮存及加工各个环节中容易受到真菌的污染，产生一系列有毒次生代谢产物（真菌毒素），直接影响药材质量的安全性与有效性，还会严重威胁人体生命健康。针对中药材中潜在的多种真菌毒素，建立高效的净化富集与灵敏、专属的检测方法，对提升中药质量标准、保障中药用药安全具有重要意义。通过对国内外重要真菌毒素的限量标准、中药材中真菌毒素检测使用的样品前处理方法、关键检测技术及降解脱毒方法进行综述，并展望中药材真菌毒素研究的发展趋势，为保障中药材的质量安全提供参考。

Chinese medicinal materials (CMMs) are susceptible to the contamination by fungi during all stages of the cultivation, harvesting, storage, and processing, producing a series of toxic secondary metabolites (dubbed mycotoxins), which directly affect the clinical safety and effectiveness of CMMs and seriously threaten human health. Establishment of the efficient purification and enrichment approaches, and the sensitive and specific detection technologies targeting at the various potential mycotoxins contained in CMMs, is essential for improving the quality standards of CMMs and ensuring its safety. This review article gave a summary on the limitation standards of key mycotoxins at home and abroad, and reviewed the sample pretreatment, crucial detection and degradation detoxification methods used in the detection of mycotoxins in CMMs, and prospected the development trendency of the researches on mycotoxins from CMMs, which provides the reference for ensuring the quality and safety of CMMs.

R286

现代中医药海河实验室科技项目（22HHZYSS00012）；组分中药国家重点实验室资助课题（CBQM2022103）