目的 基于现代制剂和古方标准煎液的质量一致性研究，优选玉女煎现代提取工艺参数。方法 以玉女煎指标成分转移率和浸膏得率为评价指标，建立15批玉女煎标准煎液关键参数的范围，以其为标准，通过单因素和正交试验对玉女煎现代制剂工艺参数进行筛选。在分析中采用客观赋权法，确定评价指标的权重系数计算综合评分，并以15批标准煎液平均值综合评分为基准值，设计公式最终评分（Y）=1/|综合评分-15批标准煎液平均值综合评分|对综合评分进行预处理作为正交试验最终评分，筛选玉女煎提取最佳工艺。结果 传统计算方法筛选的工艺制备的水提液浸膏得率超出标准煎液范围。通过客观赋权法和优化计算方式的实验显示各项指标均在15批标准煎液的范围内，筛选的玉女煎提取工艺为加水量10倍量，浸泡15 min，提取30 min。结论 按照经方现代制剂的研究要求，采用客观赋权法和优化的计算方式筛选的玉女煎提取工艺制备提取液更接近于玉女煎标准煎液，为经典名方工艺筛选提供了新的思路和方法。

Objective Based on the quality consistency study of modern preparations and standard decoction of ancient formula, the modern extraction process parameters of Yunv Decoction (YD, 玉女煎) were optimized. Methods Taking the transfer rate of the index components and the yield of extract of YD as the evaluation indexes, the range of key parameters of the standard decoction of 15 batches of YD was established. After setting the standards, the process parameters of modern pharmaceutical preparation of YD were screened by single-factor and orthogonal tests. In the analysis, the objective weighting method was used to determine the weight coefficients of evaluation indicators to calculate the comprehensive score. With the average comprehensive score of 15 batches of standard decoction as base value, the formula final score (Y)=1/|comprehensive score-average comprehensive score of 15 batches of standard decoction|was designed to pretreat the comprehensive score of orthogonal experiment, which was used as the final score of orthogonal experiment to screen the best extraction method of YD. At the same time, the rationality of the new algorithm is verified by confirmatory experiments. Results The yield of water extract extractum prepared by the process screened by the traditional calculation method exceeds the range of standard decoction. The extraction process of YD screened by the optimization algorithm is as follows:add 10 times the amount of water, soak for 15 min, and extract for 30 min. At the same time, the verification experiment showed that all the indexes were within the range of 15 batches of standard decoction. Conclusion According to the research requirements of modern preparations of classic prescription, the extraction solution prepared by the objective weighting method and the optimized calculation method is closer to the standard decoction of YD, which provides a new idea and method for the selection of classic prescription process.

R283.6

上海市科委科技创新项目（20S21902500）；上海市科委科技创新项目（22S21901200）；上海市中医药事业发展三年行动计划［ZY（2021-2023）-0215］；上海中医药大学预算内项目（2021LK028）