复方青黛丸（胶囊、片）是临床治疗银屑病的国家基本药物，现已广泛应用于寻常型银屑病血热证的治疗之中。尽管复方青黛制剂具有一定的临床使用优势，但因该制剂所引起的如胃肠道不适、肝损伤等不良反应正在引起关注。国家药品监督管理局曾通报了复方青黛制剂造成的不良反应。通过文献检索和总结发现复方青黛制剂中单味药青黛、绵马贯众、白鲜皮具有一定的胃肠毒性和肝毒性。因此，从药味组成、不良反应、毒性成分及毒性机制等方面对复方青黛制剂进行综述，为该药的临床合理使用奠定基础。

Compound Qingdai pill (capsule, tablet) is a national essential drug for the clinical treatment of psoriasis, and has been widely used in the treatment of blood heat syndrome of psoriasis vulgaris. Although Compound Qingdai preparation has certain advantages in clinical use, the toxic side effects such as gastrointestinal discomfort and liver injury caused by this preparation are attracting attention. The National Medical Products Administration has notified the adverse reactions caused by Compound Qingdai preparation. Through literature search and summary, it was found that the single drug in Compound Qingdai preparation, such as Qingdai (Indigo Naturalis), Mianmaguanzhong (Dryopteridis Crassirhizomatis Rhizoma) and Baixianpi (Dictamni Cortex), had certain gastrointestinal toxicity and liver toxicity. In this paper, the composition of drug taste, adverse reactions, toxic components and toxic mechanism of Compound Qingdai preparation were reviewed, which laid a foundation for the rational use of this drug in clinic.

R285

国家自然科学基金资助项目（81873194）；国家自然科学基金资助项目（82004093）；国家中医药管理局青年岐黄学者支持项目