目的 应用超网络法分析主治肾阳虚证的上市中成药，以期挖掘其临床应用、关键用药及核心处方，探寻中医药复方应用规律。方法 从中成药数据库和药智网中收集治疗肾阳虚证已上市中成药，在文献数据库中检索其临床研究，观察应用情况；以中成药涉及的疾病和症状及中药作为超网络的节点，采用Apriori算法对节点间关联规则进行分析，以相应支持度和置信度的关联组合作为超网络的边，构建肾阳虚证“病-症-药”超网络；使用Cytoscpe3.9.1软件进行网络可视化和拓扑分析，以药物超度值衡量网络中节点的重要性，由此挖掘肾阳虚证的主要疾病、核心处方和药物配伍规律。结果 筛选出191个复方，涉及药味293种，疾病43种，症状19种；其中64个复方有临床应用报道；肾阳虚证核心处方是鹿茸、肉苁蓉、淫羊藿、地黄、枸杞、人参、菟丝子、补骨脂、杜仲和附子，主要疾病是失眠和阳痿。结论 基于超网络筛选治疗肾阳虚证的核心处方，从多维度体现中医药异病同治思维，为临床诊疗与新药研发提供一定参考。

Objective To analyze the postmarketing Chinese patent drugs with the main kidney-yang deficiency by using the supernetwork method, in order to explore its clinical application, core herbs and core formula, and explore the application law of traditional Chinese medicine formula. Methods From the Chinese patent medicine database and the network of medicine intelligence network, we collected the postmarketing Chinese patent medicines for the treatment of kidney-yang deficiency syndrome, searched their clinical studies in the literature database, and observed their applications. The diseases and symptoms involved in Chinese patent medicines and traditional Chinese medicines were used as the nodes of the supernetwork, and the Apriori algorithm was used to analyze the association rules among the nodes, and the association combinations with the corresponding support and confidence were used as the edges of the supernetwork to construct the "disease-symptom-herb" supernetwork for kidney-yang deficiency. Network visualization and topological analysis were performed using the Cytoscpe3.9.1 software, and the importance of nodes in the network was measured by hyperdegree of herbs, from which the main diseases, core prescriptions and drug compounding patterns of kidney-yang deficiency syndrome were mined. Results A total of 191 formulas were selected, involving 293 kinds of medicine, 43 diseases and 19 symptoms; Among them, 64 formulas were reported for clinical application; The core formulas of kidney-yang deficiency were Lurong (Cervi Cornu Pantotrichum), Roucongrong (Cistanches Herba), Yinyanghuo (Epimedii Folium), Dihuang (Rehmanniae Radix), Gouqizi (Lycii Fructus), Renshen (Ginseng Radix et Rhizoma), Tusizi (Cuscutae Semen), Buguzhi (Psoraleae Fructus), Duzhong (Eucommiae Cortex), and Fuzi (Aconiti Lateralis Radix Praeparata). The main diseases were insomnia and impotence. Conclusion Based on the core formula of the treatment of kidney-yang deficiency, it reflects the thinking of TCM different diseases from multiple dimensions, and provides a certain reference for clinical diagnosis and treatment and new herb research and development.

R285；

中国中医科学院科技创新工程重大攻关项目；冠心病气滞血瘀证演变的多组学融合网络核心结构可变性研究（CI2021A05033）