甲基莲心碱是从睡莲科植物莲Nelumbo nucifera的种子幼叶和胚根（莲子心）中分离得到的一种具有双苄基异喹啉特殊结构的生物碱，大量研究表明其具有抗炎、抗氧化、抗肿瘤、抗心律失常、抗血栓、降压和减肥消脂等多种生物活性，在肿瘤、心血管和神经退行性疾病领域有广阔的应用前景。通过对甲基莲心碱在不同细胞和动物模型中的药理作用及作用机制进行综述，为进一步阐明甲基莲心碱的药用价值和合理开发应用提供科学依据。

Neferine, a bisbenzyl isoquinoline alkaloid isolated from the young leaves and radicle (lotus plumule) of Nelumbinis Plumula, was reported to possess anti-inflammatory, antioxidant, antitumor, antiarrhythmic, antithrombotic, antihypertensive and antiobesitic activities, which has a good prospect in treating tumors, cardiovascular and neurodegenerative diseases. This article reviews the pharmacological effects and mechanisms of neferine in different cells and animal models, which provides scientific basis for further elucidating the medicinal value and rational development and application of neferine.

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国家自然科学基金重点项目（82130119）