目的 研究天麻Gastrodia elata花茎的化学成分。方法 利用硅胶、Sephadex LH-20等各种色谱技术进行分离纯化，通过核磁图谱、IR、UV、质谱等多种方法并结合文献对分离得到的化合物进行结构鉴定。结果 从天麻花茎95%乙醇提取物的醋酸乙酯萃取物中分离得到13个化合物，分别鉴定为 (S)-6,12-二羟基-9-甲氧基-3,3-二甲基-8,9-二氢-3H,7H-苯并[2,3]氧杂䓬并[4,5-b]吡喃并[2,3-h]苯并吡喃-7-酮（1）、2-(2,4-二羟基苯基)-5-羟基-3-(2-羟基-3-甲基丁-3-烯-1-基)-8,8-二甲基- 4H,8H-吡喃并[2,3-f]苯并吡喃-4-酮（2）、桑黄酮C（3）、黑桑素H（4）、新环桑色烯（5）、morusin hydroperoxide（6）、桑辛素（7）、licofavone C（8）、环桑素（9）、交链孢酚（10）、3,4-dihydroxy-benzoic（11）、对羟基苯甲醇（12）、N-trans-grossamide（13）。结论 化合物1为新化合物，命名为降环桑色烯；化合物2～9为首次从该植物中分离得到。

Objective To study the chemical composition of Tianma (Gastrodia elata Bl.) flower stem. Methods Various chromatographic techniques such as silica gel and Sephadex LH-20 were used for separation and purification. Various spectroscopic methods, including nuclear magnetic resonance spectrum, IR, UV, and MS, combined comparison with literatures were employed to identify the structure of the separated compounds. Results A total of 13 compounds were isolated from ethyl acetate extract in the stem of Gastrodia elata, and identified as (S)-6,12-dihydroxy-9-methoxy-3,3-dimethyl-8,9-dihydro-3H,7H-benzo[2,3]oxepino[4,5-b]pyrano[2,3-h]chromen-7-one 2,3-dihydrooxepin (1), 2-(2,4-dihydroxyphenyl)-5-hydroxy-3-(2-hydroxy-3-methylbut-3-en-1-yl)-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one (2), kuwanon C (3), mornigrol H (4), neocyclomorusin (5), morusin hydroperoxide (6), morusin (7), licofavonec (8), cyclomulberrin (9), alternariol (10), 3,4-dihydroxy-benzoic (11), gastrodigenin (12), and N-trans-grossamide (13). Conclusion Compound 1 is identified as a novel compound and named degracyclomorusin. Compounds 2—9 are isolated from this plant for the first time.

R284.1

中科院扶贫专项（KFJ-FP-201905）