人参皂苷Rg₃（ginsenoside Rg₃，Rg₃）是人参中主要的活性成分之一，具有广泛的药理活性，尤其在抗肿瘤研究方面备受关注。然而，Rg₃在水中溶解度差和生物利用度低等问题极大地限制了Rg₃的临床应用。纳米给药系统在改善Rg₃水溶性差、延缓Rg₃体内代谢等方面取得了一定的进展，并已开发出具有不同诊疗功能的Rg₃纳米药物，显著提高了Rg₃的抗癌效果。通过对近年来Rg₃纳米药物及其在抗肿瘤方面的研究进行综述，为Rg₃的进一步研究提供参考。

Ginsenoside Rg₃ (Rg₃) is one of the main active ingredients in ginseng and has a wide range of pharmacological activities, especially in the field of antitumor. However, the poor solubility and low bioavailability of Rg₃ in water have greatly limited the clinical application of Rg₃. Nano drug delivery systems have made progress in improving the poor water solubility of Rg₃ and delaying the metabolism of Rg₃ in vivo, and have developed Rg₃ nanodrugs with different therapeutic functions, which have significantly improved the anti-cancer effect of Rg₃. In this paper, the recent research of Rg₃ nanomedicine and its application in antitumor was reviewed to provide a reference for further research on Rg₃.

中国医学科学院医学与健康创新工程项目资助（2021-I2M-1-071）；黑龙江省重点研发计划指导类项目（GZ20210092）