目的 分析21世纪以来大黄Rhei Radix et Rhizoma研究的发展历程与现状，梳理大黄研究主题的演化路径以及区域内的研究热点与区域间的研究差异，探讨大黄科研数据在赋能其产业提质增效进程中的优势。方法 对Web of Science（WOS）数据库中的英文文献，中国知网、万方、维普中的中文文献进行检索并进行数据清洗。利用VOSviewer、Coocation等软件对发文量、地区/作者合作网络、关键词共现、主题演化路径进行可视化分析。结果 纳入英文文献208篇，中文文献50 024篇。大黄研究进展迅速，我国在该领域依然占有主导地位，其次为美国和韩国。合作网络显示，中国与美国合作较为紧密，南京中医药大学、北京中医药大学、成都中医药大学等科研机构对于大黄的研究在国内外均具有较高的贡献度与影响力。关键词共现聚类图谱表明，传统功效物质基础筛选与作用机制分析、蒽醌类化合物的药动学研究、临床用药副作用分析等领域是当下大黄研究的主要关注点。结论 大黄科研态势发展良好，高质量研究成果不断涌现，“多元化、与产业密切相关、中医药特色鲜明、持续创新、高质量”是21世纪以来大黄研究的鲜明特征。众多科研工作者们从多元视角下的研究结果与对应的研究结论，可为进一步全面深入研究陇药大黄产业的发展潜力和新动能培育提供科学依据。

Objective To analyze the development process and current situation of Dahuang (Rhei Radix et Rhizoma) research since the 21 st century, sorts out the evolution path of Rhei Radix et Rhizoma research topics, as well as the research hotspots in the region and the research differences between regions, and discusses the advantages of Rhei Radix et Rhizoma research data in empowering its industry to improve quality and efficiency. Methods The English literature in the Web of Science (WOS) database and the Chinese literature in CNKI, Wanfang and Weipu were searched and cleaned. Using VOSviewer, Coocation and other software to visually analyze the number of publications, regional/author cooperation networks, keyword co-occurrence, and theme evolution paths. Results A total of 208 English articles and 50 024 Chinese articles were included. The research progress of Rhei Radix et Rhizoma was rapid, and China still occupies a dominant position in this field, followed by the United States and South Korea. The cooperation network shows that China and the United States have close cooperation. Scientific research institutions such as Nanjing University of Chinese Medicine, Beijing University of Traditional Chinese Medicine and Chengdu University of Traditional Chinese Medicine have a high contribution and influence on the research of Rhei Radix et Rhizoma at home and abroad. The keyword co-occurrence clustering map shows that the screening and mechanism analysis of traditional efficacy material basis, pharmacokinetic study of anthraquinone compounds, and analysis of side effects of clinical medication are the main concerns of current Rhei Radix et Rhizoma research. Conclusion The research situation of Rhei Radix et Rhizoma is developing well, and high-quality research results are constantly emerging. "Diversification, closely related to the industry, distinctive characteristics of traditional Chinese medicine, continuous innovation and high quality" are the distinctive characteristics of Rhei Radix et Rhizoma research since the 21st century. The research results and corresponding research conclusions of numerous researchers from multiple perspectives can provide scientific basis for further comprehensive and in-depth study of the development potential and new kinetic energy cultivation of Longyao Rhei Radix et Rhizoma industry.

R282.71；G350

中国工程院战略研究与咨询项目（GS2021ZDA06）；道地药材生态种植及质量保障项目（国中医药科技[2020]153号）；财政部和农业农村部：国家现代农业产业技术体系资助（CARS-21）