目的 研究菲律宾产丝沉香Aquilaria filaria的化学成分。方法 采用硅胶、凝胶、半制备高效液相色谱等多种色谱技术分离丝沉香的化学成分，通过高分辨质谱、核磁共振等波谱学方法鉴定化合物结构，采用改进后的4-硝基苯基-β-D-吡喃葡萄糖苷（4-nitrophenyl-β-D-glucopyranoside，pNPG）法测试化合物的α-葡萄糖苷酶抑制活性。结果 从菲律宾产丝沉香中分离鉴定了2个2-（2-苯乙基）色酮二聚体，分别为aquifilarone N（1 ）和diaquilariachrome B（2 ）。化合物1 和2 均具有α-葡萄糖苷酶抑制活性，半数抑制浓度（median inhibition concentration，IC₅₀）值分别为（14.33±0.38）μmol/L和（39.53±2.09）μmol/L。结论 化合物1 为新化合物，化合物2 为首次从丝沉香中分离得到。

Objective To investigate the chemical constituents of agarwood of Aquilaria filaria from Philippines. Methods All compounds were isolated by using various chromatographic techniques, including silica gel, Sephadex LH-20, semi-preparative high performance liquid chromatography. Their structures were elucidated based on modern spectroscopic methods, such as high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR). The α-glucosidase inhibition assay was performed by modified pNPG (4-nitrophenyl β-D-glucopyranoside) method. Results Two 2-(2-phenylethyl) chromone dimers were isolated from agarwood of A. filaria, and identified as aquifilarone N (1) and diaquilariachrome B (2). Compounds 1 and 2 exhibited α-glucosidase inhibitory activities in vitro, with IC₅₀ values of (14.33 ±0.38)μmol/L and (39.53 ±2.09) μmol/L, respectively. Conclusion Compound 1 is a new compound, and compound 2 is isolated from A. filaria for the first time.

R284.1

海南省重大科技计划项目（ZDKJ2021031）；财政部和农业农村部国家现代农业产业技术体系（CARS-21）；海南省自然科学基金高层次人才项目（320RC714）；中央级公益性科研院所基本科研业务费专项（1630052023006）