随着有机溶液在中药制药领域应用的逐渐普遍，涉及到提取、醇沉、树脂洗脱剂成分制备等环节，从而衍生出衔接性的热处理精制引起中药成分转化、溶剂污染等问题。纳滤具有常温化分离优势，但适用于水溶液的分离模型在有机溶液中存在明显的局限性。通过综述纳滤分离机制，结合复杂溶液体系下中药成分的真实状态和传质行为，以期发现适用于有机溶液环境的中药成分纳滤分离研究策略，提升纳滤技术在中药制药领域的适用性，推动中药资源的合理化利用。

With the gradual popularization of the application of organic solutions in Chinese medicine, it involves extraction, alcohol precipitation, preparation of resin eluent components and other links, thus deriving problems such as transformation of Chinese medicine components and solvent pollution caused by the cohesive refining link heat treatment. Nanofiltration has the advantage of constant temperature refining and separation, but the separation model suitable for aqueous solution has obvious limitations in organic solution. By reviewing the separation mechanism of nanofiltration and combining with the real state and mass transfer behavior of the components of Chinese medicine in complex solution systems, we hope to find the research strategy of the separation mechanism of Chinese medicine components suitable for organic solution environment, improve the applicability of nanofiltration technology in the field of Chinese medicine pharmacy, and promote the rational utilization of traditional Chinese medicine resources.

R283

国家自然科学基金资助项目（82274106）；江苏省自然科学基金资助项目（BK20211303）；江苏省333高层次人才培养工程；2023年国家级大学生创新创业训练计划资助项目（202310315046Z）；2023年江苏省研究生科研与实践创新项目（KYCX23_2047）