铁死亡是一种新型的细胞死亡形式，与铁过载和脂质过氧化有关，在许多疾病的发展中具有重要作用。骨质疏松症、骨关节炎、类风湿关节炎、骨肉瘤、脊髓损伤、肌少症等肌肉骨骼系统疾病严重影响患者生活质量，已成为全球公共卫生系统的主要负担。铁死亡与上述肌肉骨骼系统疾病的发生发展密切相关，表明铁死亡可能成为肌肉骨骼系统疾病的治疗的新靶点。中医药在肌肉骨骼系统疾病治疗中有其独特的优势，已有大量研究证实中医药通过铁死亡途径参与肌肉骨骼系统疾病的调节，显示出良好的研究前景。通过探讨铁死亡与肌肉骨骼系统疾病的关联，总结中医药通过介导铁死亡防治肌肉骨骼系统疾病研究进展，为开发新的治疗策略及中医药更好的治疗肌肉骨骼系统疾病治疗提供思路。

Ferroptosis is a new form of cell death, which is related to iron overload and lipid peroxidation, and plays an important role in the development of many diseases. Osteoporosis, osteoarthritis, rheumatoid arthritis, osteosarcoma, spinal cord injury, sarcopenia and other musculoskeletal diseases seriously affect the quality of life of patients and have become the main burden of the global public health system. Ferroptosis is closely related to the occurrence and development of the above musculoskeletal diseases, indicating that ferroptosis may become a new target for the treatment of musculoskeletal diseases. Traditional Chinese medicine has its unique advantages in the treatment of musculoskeletal diseases. A large number of studies have confirmed that traditional Chinese medicine participates in the regulation of musculoskeletal diseases through the ferroptosis pathway, showing good research prospects. By exploring the relationship between ferroptosis and musculoskeletal diseases, this paper summarizes the research progress of traditional Chinese medicine in preventing and treating musculoskeletal diseases by mediating ferroptosis, and provides ideas for the development of new treatment strategies and better treatment of musculoskeletal diseases by traditional Chinese medicine.

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陕西省中医药管理局“骨退行性疾病中西医结合防治‘双链融合’中青年科研创新团队”（2022-SLRH-LJ-001）；陕西中医药大学学科建设创新团队（骨关节及脊椎退行性疾病中西医结合防治创新团队2019YL-02）；长安医学关中李氏骨伤学术流派传承工作室建设项目（陕中医药发[2018]40号）；陕西省骨退行性疾病中西医结合防治重点研究室建设项目（陕中医药发[2018]32号）