木犀草素属于黄酮类化合物，是天然抗氧化剂，具有丰富的生物活性，可调节众多与疾病进展有关的细胞内和细胞外信号通路，具有抗氧化、抗炎、抗糖尿病、抗癌等作用。由于低溶解度和生物利用度等限制了其在临床上的应用。然而，木犀草素的低相对分子质量和易修饰的化学基团，使其具有药物开发的吸引力。通过对木犀草素的结构修饰及其衍生物的生物活性进行综述，为天然产物的研究、开发及利用提供参考。

Luteolin is a flavonoid, a natural antioxidant, with rich biological activities, which can regulate many intracellular and extracellular signaling pathways related to disease progression, and has antioxidant, anti-inflammatory, anti-diabetic, anti-cancer and other effects. Due to the low solubility and low bioavailability, the clinical application is limited. However, luteolin's low relative molecular weight and easily modified chemical groups make it attractive for drug development. Therefore, the structural modification of luteolin and the biological activities of its derivatives were reviewed to provide reference for the research, development and utilization of natural products.

R282.710.85

郑州市高等学校名师技术技能工作室（郑教高[2015]70号）；河南省科技攻关项目（232102310391）