目的 通过对近20年柴胡相关研究的文献分析，探析柴胡研究领域的相关热点与前沿。方法 以中国知网（CNKI）、万方（Wanfang）、维普（VIP）以及Web of Science（WOS）等国内外数据库为数据源，运用COOC对数据进行处理筛选，运用VOSviewer对文献年度发文量、机构、关键词、作者等内容进行分析，绘制可视化图谱。结果 共纳入中文文献64 919篇，英文文献200篇。文献数量整体呈增长趋势；研究机构主要以中南大学和北京中医药大学为代表；中、英文关键词显示，柴胡的主要研究方向为柴胡皂苷、柴胡疏肝散、药动学、小柴胡汤等；目前柴胡的研究热点主要为柴胡皂苷、中医药疗效、临床应用以及柴胡的相关方剂等。结论 柴胡研究目前处于快速发展阶段，该领域的最新进展主要集中于对其临床疗效、药理作用的靶点、信号通路以及基因层面的深入研究等。

Objective To analyze the relevant hot spots and frontiers in the research field of Chaihu (Bupleuri Radix) through the literature analysis of Bupleuri Radix related research in the past 20 years. Methods Using domestic and foreign databases such as CNKI, Wanfang, VIP and Web of science (WOS) as data sources, COOC was used to process and screen the data, and VOSviewer was used to analyze the annual number of publications, institutions, keywords, authors and other contents, and visualization maps were drawn. Results A total of 64 919 Chinese literatures and 200 English literatures were included, and the number of literature showed an overall increasing trend. The research institutions were mainly represented by Central South University and Beijing University of Chinese Medicine. Keywords in both Chinese and English showed that the main research directions of Bupleuri Radix were saikosaponin, Chaihu Shugan San (柴胡疏肝散), pharmacokinetics, Xiaochaihu Decoction (小柴胡汤), etc. At present, the research focus of Bupleuri Radix mainly included saikosaponin, curative effect of traditional Chinese medicine, clinical application and relevant prescriptions of Bupleuri Radix. Conclusion The research of Bupleuri Radix was currently in a rapid development stage. The latest progress in this field mainly focuses on its clinical efficacy, pharmacological targets, signaling pathways and gene levels.

中国工程院战略研究与咨询项目（GS2021ZDA06）；道地药材生态种植及质量保障项目（国中医药科技[2020]153号）；财政部和农业农村部：国家现代农业产业技术体系资助（CARS-21）；甘肃省珍稀中药资源评价与保护利用工程研究中心开放基金（GSZXZY202203）