龙血竭Resina Draconis具有活血化瘀、消炎镇痛、生肌敛疮之功效，作为我国传统中药材及民族特色药材，常被称为“国产血竭”。现代研究表明龙血竭具有保护心脑血管系统、神经系统及抗肿瘤、促进组织愈合等药理作用，化学成分包括酚类、萜类、甾醇类等，活性成分以酚类为主，如紫檀茋、龙血素A、龙血素B、白藜芦醇等。大量研究已证实龙血竭能有效干预脑、心、肾等重要组织脏器的缺血再灌注损伤，对临床应用具有重要意义。通过梳理近十年国内外相关研究，总结了龙血竭及其主要酚类活性成分在抗氧化应激、抗炎、神经保护、保护血脑屏障、抗血栓等方面的药理作用及可能的作用机制，以期为该药在脑缺血防治领域的深入研发提供参考借鉴，助力其临床合理优效应用。

As a traditional Chinese medicine with ethnic characteristics, Resina Draconis has the functions of activating blood circulation and removing blood stasis, reducing inflammation and analgesia, promoting muscle and healing sores, also known as “domestic Draconis Sanguis” with a long history of usage. Modern research has shown that Resina Draconis has pharmacological effects in protecting the cardiovascular and nervous systems, anti-tumor activity, and promoting tissue healing. The active ingredients of Resina Draconis are mainly phenols, terpenoids and steroids, such as pterostilbene, loureirin A, loureirin B and resveratrol. A large number of studies have provided substantial evidence that Resina Draconis can effectively intervene in the ischemia-reperfusion injury of brain, heart, kidneys and other vital organs, which is of great significance for clinical application. In the review, the pharmacological effects and possible mechanisms of Resina Draconis in anti-oxidative stress, anti-inflammatory properties, neuroprotection, protection of the blood-brain barrier, and anti-thrombotic were systematically summarized based on both domestic and foreign studies in recent 10 years. It is expected to provide a reference for the future development of Resina Draconis in the field of cerebral ischemia prevention and treatment to facilitate its clinical application.

国家自然科学基金资助项目（81973744）；中国医学科学院医学与健康科技创新工程项目（N2022-I2M-2-001，2022-I2M-1-018）；北京市自然科学基金资助项目（7173267）