柴胡Bupleuri Radix辛、苦，微寒，具有疏散退热、疏肝解郁、升举阳气的功效。柴胡在临床中应用广泛，但是在产生药效的同时，其不良反应也时有发生，并且逐渐引起重视，其中所引起的主要不良反应是肝毒性。通过查阅柴胡有关毒性的文献，对柴胡所引起的不良反应、主要毒性成分、影响毒副作用的因素、毒性原因辨析、减毒策略等方面进行整理总结，为柴胡的用药安全提供参考。

Chaihu (Bupleuri Radix) is pungent and bitter in flavor and slightly cold in nature, it has the effects of relieving the surface and reducing fever, soothing the liver and relieving depression, and boosting yang. Bupleuri Radix is widely used in clinical practice, but its toxic and side effects also occur from time to time while producing efficacy, which has attracted attention gradually. The main toxic and side effect caused by Bupleuri Radix is hepatotoxicity. In this paper, the toxic and side effects caused by Bupleuri Radix, the main toxic components, the factors affecting the toxic side effects, the analysis of the causes of toxicity, and the strategies for reducing toxicity were summarized by consulting the relevant toxic literature of Bupleuri Radix, with a view to providing a reference for the safety use of Bupleuri Radix.

R285.53

国家自然科学基金资助项目（82204799）；国家自然科学基金资助项目（81873194）；国家中医药管理局青年歧黄学者支持项目