异甘草素是甘草中的黄酮类化合物，具有抗肿瘤、抗氧化、抗炎等药理作用，近年来在抗肿瘤领域备受关注。研究发现异甘草素具有广谱高效的抗肿瘤活性，但因其水溶性差、生物利用度低、非特异性靶向等缺点而限制了临床的广泛应用，新型给药系统的出现有望改善异甘草素的溶解度、提高生物利用度、降低不良反应等，具有良好的应用前景。通过对近年来国内外文献中关于异甘草素的理化性质、抗肿瘤药理活性及其纳米粒、脂质体、聚合物胶束等抗肿瘤新型给药系统研究进展的梳理，为异甘草素新型给药系统在肿瘤治疗领域的发展与应用提供参考与借鉴。

Isoliquiritigenin is a flavonoid compound in licorice with antitumor, antioxidant, anti-inflammatory, and other pharmacological effects, which has attracted much attention in the field of antitumor in recent years. It is found that isoliquiritigenin has broad-spectrum and efficient antitumor activity, however, its poor water solubility, low bioavailability, non-specific targeting, and other shortcomings have limited its wide clinical application, the emergence of new drug delivery systems is expected to improve the solubility of isoliquiritigenin, improve bioavailability, reduce toxic side effects, etc., and has good application prospects. The research progresses on the physicochemical properties, antitumor pharmacological activities of isoliquiritigenin and its new antitumor drug delivery systems such as nanoparticles, liposomes, and polymeric micelles in recent years are reviewed to provide a reference for the development and application of new drug delivery systems of isoliquiritigenin in the field of tumor therapy.

R283；R285

中国中医科学院科技创新工程项目（CI2021A04305）；中国中医科学院科技创新工程项目（CI2021B014）；中央级公益性科研院所基本科研业务费专项（ZXKT21013）；中央级公益性科研院所基本科研业务费专项（ZZ13-YQ-041）