“寒性”是中药特有的药性之一，酒制可缓和中药的“寒性”。需酒制的“寒性”中药大多具清热解毒、活血、泻下等功效，此外，部分“寒性”中药因“寒性”过偏，表现出泄泻、腹痛等不良反应。酒制可引药上行、增强疗效，降低其毒副作用，使“寒性”中药安全、有效地满足临床需求。通过对酒制改变“寒性”中药的主要功效、物质基础、不良反应等方面进行综述，并提出可行性研究思路，为“寒性”中药的临床应用提供科学依据，亦可为酒制“寒性”中药的进一步研究提供方法借鉴。

“cold property” is one of unique Chinese medical properties of traditional Chinese medicine (TCM), and processing with wine can alleviate the “cold property” of TCM. Most of the “cold property” TCM that need to be processed with wine possess the effects of antipyretic with antidote, promoting blood circulation, and purging. In addition, some of the “cold property” TCM have toxic and side effects such as diarrhea and abdominal pain due to excessive “cold property”. Processing with wine can promote the drug upwards, enhance the curative effect, reduce its toxic and side effects, so that “cold property” TCM can be used safely and effectively in clinical needs. This article summarized the influence of processing with wine on the main efficacy, material basis and side effects of “cold property” TCM, and put forward a feasible research idea, which aiming to provide scientific basis for the clinical application of “cold property” TCM, and can also provide a reference for the further research of “cold property” TCM.

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国家自然科学基金资助项目（82104396）；国家自然科学基金资助项目（81974525）；陕西省中医药管理局科研项目（2021-ZZ-JC012）；陕西省教育厅科研项目（21JK0592）；陕西中医药大学学科创新团队项目（2019-YL10）；省级大学生创新创业训练计划项目（S202210716074，202110716043）