补骨脂Psoralea Fructus具有温肾壮阳、健脾等功效，但因辛热而燥，长用有伤阴之嫌，炮制可缓和偏燥之性，在我国传统中医药历史上应用广泛。通过查阅相关医学典籍及文献，对补骨脂的炮制方法历史沿革及现代炮制机制的研究进展进行总结。从化学成分可测性、成分与传统功效相关性、药动学及体内过程等对补骨脂的质量标志物（quality marker，Q-Marker）进行预测分析，初步确定补骨脂素、异补骨脂素、补骨脂二氢黄酮、补骨脂异黄酮、新补骨脂异黄酮、补骨脂酚等为其可能的Q-Marker，为补骨脂的炮制工艺传承、质量标准制定以及临床应用提供参考。

Buguzhi (Psoralea Fructus) has the effect of warming the kidneys, assisting the yang, and strengthening the spleen, but because it is pungent-hot and dry, its prolonged use is suspected of harming yin. It can be tempered by processing and is therefore widely used in traditional Chinese medicine. The historical evolution of processing methods and the research progress of the modern processing mechanism of Psoralea Fructus were summarized by consulting the related medical classics and literature. The quality marker (Q-Marker) of Psoralea Fructus was predicted in terms of measurable chemical components, the correlation between composition and traditional efficacy, pharmacokinetics, and metabolic processes. Psoralen, isopsoralen, bavachin, corylin, neobavaisoflavone, and bakuchiol are preliminarily identified as possible Q-Markers. This study can provide a reference for the inheritance of the concoction process, quality standard development, and clinical application of Psoralea Fructus.

R285

山东中医药科技发展计划项目（2019-0079）