动脉粥样硬化已成为导致全球人类死亡的主要原因，且发病率呈上升和年轻化趋势。中药在我国用药历史悠久、底蕴深厚，但作用机制研究仍不明晰。明确动脉粥样硬化的发生机制及中药对其的防治作用对后续有针对性的研究中药改善动脉粥样硬化具有重要作用。通过从炎症、氧化应激、细胞焦亡、自噬、铁死亡等方面综合阐述动脉粥样硬化的发病机制及中药成分在各相关机制的具体应用研究，为充分发挥传统中医药在医学领域的作用，提升传统中医药的国际地位，更好的防治动脉粥样硬化夯实理论基础。

Atherosclerosis has become the main cause of human mortality worldwide, the rise of incidence rate and the younger age of onset. Traditional Chinese medicine has a long and profound history of medication in China, but the research on its mechanism of action is not thorough enough. clarifying the mechanism of atherosclerosis and the prevention and treatment effect of traditional Chinese medicine on it plays a crucial role in inhibiting atherosclerosis in subsequent targeted research. This article comprehensively expounds the pathogenesis of atherosclerosis and the specific application of traditional Chinese medicine ingredients in various related mechanisms from the aspects of inflammation, oxidative stress, cell pyroptosis, autophagy and ferroptosis. In order to give full play to the role of traditional Chinese medicine in the field of medicine, enhance the international status of traditional Chinese medicine, better prevention and treatment of atherosclerosis to lay a solid theoretical foundation.

R285

国家自然科学基金资助项目（81960730）；广西研究生教育创新计划项目（YCSY2022044）