目的 应用星点设计-响应面法优化厚朴Magnolia officinalis产地趁鲜加工与炮制一体化工艺。方法 通过CRITIC法计算厚朴饮片外观性状和主要有效成分厚朴酚、和厚朴酚含量3个指标的权重系数，采用Box-Behnken响应面法，以综合评分作为评价指标，考察干燥温度、干燥时间和切丝宽度3个因素对厚朴饮片的影响，优化厚朴产地趁鲜加工与炮制一体化工艺。结果 利用CRITIC法确定厚朴饮片外观性状、和厚朴酚含量、厚朴酚含量的权重系数分别为0.422 1、0.241 0、0.336 9，优选的厚朴饮片炮制工艺为厚朴药材去粗皮后，切7 mm厚的丝装入内膜袋于烘箱内40 ℃发汗16 h后，平铺在烘箱内65 ℃干燥14.5 h。验证结果与预测值之间的RSD为1.76%，说明模型具有良好的预测性。结论 优化的厚朴产地趁鲜加工与炮制一体化工艺简便易行，稳定性好，可为以厚朴为代表的“发汗”类皮类饮片规范化生产和质量标准提高提供参考。

Objective To optimize the integration of fresh processing and processing process of Houpo (Magnolia officinalis) production area by star point design-response surface method. Methods The weighting coefficients of the appearance properties, and the main active ingredient, magnolol, and honokiol content of M. officinalis decoction pieces were calculated by CRITIC method, and the Box-Behnken response surface method was used to investigate the effect of drying temperature, drying time and shredding width on the comprehensive score of M. officinalis decoction pieces, and the integration of fresh processing and processing process of M. officinalis was optimized. Results The weight coefficients of CRITIC method was used to determine the appearance properties, magnolol content and honokiol content, which were 0.422 1, 0.241 0 and 0.336 9, respectively. The preferred processing process of M. officinalis decoction pieces was to remove the raw bark of M. officinalis medicinal materials, cut 7 mm thick silk, put it into an inner film bag in an oven and sweat at 40 ℃ for 16 h, then spread it in the oven and dry at 65 ℃ for 14.5 h. The RSD between the validation results and the predicted values is 1.76%, indicating that the model has good predictability. Conclusion The optimized integration of fresh processing and processing process of M. officinalis is simple and stable, which can provide reference for standardized production and quality standards of “sweating” skin decoction pieces represented by M. officinalis.

R283.6

四川省科技计划重点研发项目（2020YFN0152）；四川省科技厅重点研发计划（重大科技专项）社会发展领域重点研发项目（2022YFS0582）；国家中医药管理局中医药创新团队及人才支持计划项目（ZYYCXTD-D-202209）；成都中医药大学杏林学者青基人才专项（QJRC2022034）